Multiple simple renal cysts have been linked to aortic aneurysm and connective tissue disease by different authors. We present a case of a 64-year-old male patient with multilevel, rapid progressive aneurysmatic disease. Over a period of 11 years, he sequentially developed a symptomatic infrarenal aortic aneurysm of 100 mm, a juxtarenal progression of the aneurysm up to 61 mm, an aneurysm on the descending thoracic aorta of 73 mm, and a common iliac aneurysm of 53 mm. In addition, he developed an aneurysm of 69 mm of the left superficial femoral artery and an aneurysm of 53 mm of the right profunda femoris artery. Although the exact relationship between multiple simple renal cysts and arterial aneurysm formation is not known, there is a suggestion that they can be a marker for arterial aneurysmatic disease. We therefore would advocate a more thorough follow-up in case of aneurysmatic disease in a patient with known multiple simple renal cysts.