Abstract
Objectives: To explore the relationships of muscle endurance with circulating Interleukin (IL)-6, Tumor Necrosis Factor (TNF)-alpha and Heat Shock Protein (Hsp)70 in nursing home residents, and to assess how muscle endurance related to self-perceived fatigue and mobility.
Design: Exploratory study
Setting: Three nursing homes of the Foundation for Psychogeriatrics (Brussels, Belgium).
Participants: Seventy-seven residents (53 female and 24 male, mean age 81±8 years).
Measurements: Participants were assessed for muscle endurance (fatigue resistance and grip work), perceived fatigue (Visual Analogue Scale for Fatigue), fatigue during daily activities (Mobility-Tiredness scale), impact of fatigue on quality of life (World Health Organization Quality Of Life questionnaire), mobility (Tinetti test & Elderly Mobility Scale [EMS]) and circulating IL-6, TNF-alpha and Hsp70.
Results: Residents with better fatigue resistance reported less self-perceived tiredness (pConclusion: Elderly nursing home residents complaining of fatigue need to be taken seriously since they show worse muscle endurance, which is related to reduced mobility. Inflammatory processes involving TNF-alpha and the interaction between IL-6 and Hsp70 are related to reduced muscle endurance in these patients.
Design: Exploratory study
Setting: Three nursing homes of the Foundation for Psychogeriatrics (Brussels, Belgium).
Participants: Seventy-seven residents (53 female and 24 male, mean age 81±8 years).
Measurements: Participants were assessed for muscle endurance (fatigue resistance and grip work), perceived fatigue (Visual Analogue Scale for Fatigue), fatigue during daily activities (Mobility-Tiredness scale), impact of fatigue on quality of life (World Health Organization Quality Of Life questionnaire), mobility (Tinetti test & Elderly Mobility Scale [EMS]) and circulating IL-6, TNF-alpha and Hsp70.
Results: Residents with better fatigue resistance reported less self-perceived tiredness (pConclusion: Elderly nursing home residents complaining of fatigue need to be taken seriously since they show worse muscle endurance, which is related to reduced mobility. Inflammatory processes involving TNF-alpha and the interaction between IL-6 and Hsp70 are related to reduced muscle endurance in these patients.
| Original language | English |
|---|---|
| Pages (from-to) | 389-396 |
| Number of pages | 8 |
| Journal | Journal of the American Geriatrics Society |
| Volume | 56 |
| Issue number | 3 |
| Publication status | Published - 2008 |
Keywords
- Heat Shock Protein
- Cytokines
- Muscle Endurance
- Nursing Homes
- Elderly