Myelomonocytic subsets in tumor microenvironment

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1 Citation (Scopus)

Abstract

Macrophages perform very diverse functions in the body by contributing to tissue generation and homeostasis, but also by initiating and dampening inflammation. Since one single cell type needs to accommodate such diverse functions, macrophages can adopt diverse activation states and express a diverse molecular repertoire in response to a changing microenvironment. Owing to their heterogeneity, macrophages may be implicated in all phases of cancer development, from inflammation-associated carcinogenesis to immunosurveillance, tumor progression and metastasis. At the tumor site, tumor-associated macrophages (TAM) reside in different locations, giving rise to TAM subpopulations with specialized functions. In addition, other types of myeloid cells such as myeloid-derived suppressor cells (MDSC) and Tie2-expressing monocytes (TEM) are found inside tumors and complement TAMs to support tumor progression. An improved knowledge of the molecular and functional heterogeneity of tumor-associated myeloid cells is warranted and would provide a basis for the development of novel therapies that target these tumor-promoting cells.
Original languageEnglish
Title of host publicationMacrophages: biology and role in the pathology of diseases
EditorsS.k. Biswas, A. Mantovani
PublisherSpringer
Pages405-423
Number of pages19
ISBN (Electronic)978-1-4939-1311-4
ISBN (Print)978-1-4939-1310-7
Publication statusPublished - 1 Jan 2014

Bibliographical note

S.K. Biswas, A. Mantovani

Keywords

  • tumor-associated macrophages
  • M1
  • M2
  • Myeloid-derived suppressor cells
  • Tie2-expressing monocytes
  • hypoxia
  • ER stress
  • exosomes

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