Abstract
Abstract: The Pictet-Spengler reaction is known as a useful tool for the synthesis of constrained analogs of tryptophan. Herein, we present the further cyclization of 1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid methyl esters with 1-(1'-aminoalkyl) side chain. These transformations lead to heterocyclic structures which can find useful applications in medicinal chemistry as peptide mimetics
| Original language | English |
|---|---|
| Pages (from-to) | 97-108 |
| Number of pages | 12 |
| Journal | Molecular Diversity |
| Volume | 14 |
| Issue number | 1 |
| Publication status | Published - 1 Feb 2010 |
Keywords
- Peptidomimetics
- Cyclization
- Fused ring system
- Imidazolidin-2-ones
- midazolidines
- Piperazin-2-ones