New tetracyclic tetrahydro-beta-carbolines as tryptophan-derived peptidomimetics

Karolina Pulka, Debby Feytens, A Misicka, Dirk Tourwe

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Abstract: The Pictet-Spengler reaction is known as a useful tool for the synthesis of constrained analogs of tryptophan. Herein, we present the further cyclization of 1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid methyl esters with 1-(1'-aminoalkyl) side chain. These transformations lead to heterocyclic structures which can find useful applications in medicinal chemistry as peptide mimetics
Original languageEnglish
Pages (from-to)97-108
Number of pages12
JournalMolecular Diversity
Volume14
Issue number1
Publication statusPublished - 1 Feb 2010

Keywords

  • Peptidomimetics
  • Cyclization
  • Fused ring system
  • Imidazolidin-2-ones
  • midazolidines
  • Piperazin-2-ones

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