No evidence of varicella-zoster virus infection in temporal artery biopsies of anterior ischemic optic neuropathy patients with and without giant cell arteritis

Robert M Verdijk, Werner J D Ouwendijk, Robert W A M Kuijpers, Georges M G M Verjans

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

BACKGROUND: To test the hypothesis that varicella-zoster virus (VZV) infection contributes to temporal arteritis pathogenesis, comprehensive in situ analysis was performed on temporal artery biopsies of 38 anterior ischemic optic neuropathy (AION) patients, including 14 (37%) with giant cell arteritis.

METHODS: Biopsies were completely sectioned, and, on average, 146 serial sections per patient were stained for VZV glycoprotein E.

RESULTS: Four of 38 AION patients showed VZV glycoprotein E staining, but VZV infection was not confirmed by staining for VZV IE63 protein and VZV-specific polymerase chain reaction on adjacent sections.

CONCLUSIONS: This study refutes the premise that VZV is casually related to AION with and without giant cell arteritis.

Original languageEnglish
Pages (from-to)109-112
Number of pages4
JournalThe Journal of Infectious Diseases
Volume223
Issue number1
Early online date9 Sep 2020
DOIs
Publication statusPublished - 1 Jan 2021

Bibliographical note

© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

Keywords

  • PCR
  • Temporal arterial biopsies
  • anterior ischemic optic neuropathy
  • giant cell arteritis
  • immunohistochemistry
  • nonspecific staining
  • varicella-zoster virus

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