BACKGROUND: To test the hypothesis that varicella-zoster virus (VZV) infection contributes to temporal arteritis pathogenesis, comprehensive in situ analysis was performed on temporal artery biopsies of 38 anterior ischemic optic neuropathy (AION) patients, including 14 (37%) with giant cell arteritis.
METHODS: Biopsies were completely sectioned, and, on average, 146 serial sections per patient were stained for VZV glycoprotein E.
RESULTS: Four of 38 AION patients showed VZV glycoprotein E staining, but VZV infection was not confirmed by staining for VZV IE63 protein and VZV-specific polymerase chain reaction on adjacent sections.
CONCLUSIONS: This study refutes the premise that VZV is casually related to AION with and without giant cell arteritis.
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- Temporal arterial biopsies
- anterior ischemic optic neuropathy
- giant cell arteritis
- nonspecific staining
- varicella-zoster virus