Non-canonical roles of connexins.

Raf Van Campenhout; Axelle Cooreman; Kaat Leroy; Olga Martyna Rusiecka; Pieter Van Brantegem; Pieter Annaert; Serge Muyldermans; Nick Devoogdt; Bruno Cogliati; Brenda R. Kwak; Mathieu Vinken

doi:10.1016/j.pbiomolbio.2020.03.002

Non-canonical roles of connexins.

Raf Van Campenhout, Axelle Cooreman, Kaat Leroy, Olga Martyna Rusiecka, Pieter Van Brantegem, Pieter Annaert, Serge Muyldermans, Nick Devoogdt, Bruno Cogliati, Brenda R. Kwak, Mathieu Vinken

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

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Abstract

Gap junctions mediate cellular communication and homeostasis by controlling the intercellular exchange of small and hydrophilic molecules and ions. Gap junction channels are formed by the docking of 2 hemichannels of adjacent cells, which in turn are composed of 6 connexin subunits. Connexin proteins as such can also control the cellular life cycle independent of their channel activities. This has been most demonstrated in the context of cell growth and cell death. Different mechanisms are involved mainly related to direct interaction with cell growth or cell death regulators, but also implying effects on the expression of cell growth and cell death regulators. The present paper focuses on these atypical roles of connexin proteins.

Original language	English
Pages (from-to)	35-41
Number of pages <span style="color:red"p> <font size="1.5"> ✽ </span> </font>	7
Journal	Progress in Biophysics and Molecular Biology
Volume	153
DOIs	https://doi.org/10.1016/j.pbiomolbio.2020.03.002
Publication status	Published - Jul 2020

Bibliographical note

Funding Information:
This work was financially supported by grants of the Fund for Scientific Research-Flanders (FWO-Vlaanderen), the University Hospital of the Vrije Universiteit Brussel-Belgium (Willy Gepts Fonds UZ-Brussel) , the Fundação de Amparo à Pesquisa do Estado de São Paulo ( FAPESP - FWO grant 18/10953-9 ) and the FWO / SNSF Lead Agency project funding (SNSF no. 310030E_176050 ).

Funding Information:
This work was financially supported by grants of the Fund for Scientific Research-Flanders (FWO-Vlaanderen), the University Hospital of the Vrije Universiteit Brussel-Belgium (Willy Gepts Fonds UZ-Brussel), the Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP-FWO grant 18/10953-9) and the FWO/SNSF Lead Agency project funding (SNSF no. 310030E_176050).

Publisher Copyright:
© 2020 Elsevier Ltd

Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.

Keywords

connexin
cell growth
cell death

Access to Document

10.1016/j.pbiomolbio.2020.03.002

paperAccepted author manuscript, 727 KBLicence: CC BY-NC-ND

2 Active
4 Finished

SRP50: SRP-Onderzoekszwaartepunt: Exploiting Peptides: Protein Binders, Modulators and Inhibitors for Imaging and Therapy [Exploit-PeptIT]
Ballet, S., Caveliers, V., Hernot, S., Versées, W., Vinken, M., Muyldermans, S., Devoogdt, N., Bridoux, J. & Martin, C.
1/03/19 → 30/09/25
Project: Fundamental
OZR2275: Connexin and pannexin channels: function, regulation and applications
Vinken, M. & Leybaert, L.
1/09/11 → …
Project: Fundamental
FWOSB75: Connexin hemichannels and pannexin channels as mediators and in vitro indicators of drug-induced cholestatic liver injury.
Vinken, M. & Cooreman, A.
1/11/19 → 31/10/23
Project: Fundamental

Cite this

@article{3de3f2d99180427798b0d95e363dd948,

title = "Non-canonical roles of connexins.",

abstract = "Gap junctions mediate cellular communication and homeostasis by controlling the intercellular exchange of small and hydrophilic molecules and ions. Gap junction channels are formed by the docking of 2 hemichannels of adjacent cells, which in turn are composed of 6 connexin subunits. Connexin proteins as such can also control the cellular life cycle independent of their channel activities. This has been most demonstrated in the context of cell growth and cell death. Different mechanisms are involved mainly related to direct interaction with cell growth or cell death regulators, but also implying effects on the expression of cell growth and cell death regulators. The present paper focuses on these atypical roles of connexin proteins.",

keywords = "connexin, cell growth, cell death",

author = "{Van Campenhout}, Raf and Axelle Cooreman and Kaat Leroy and Rusiecka, {Olga Martyna} and {Van Brantegem}, Pieter and Pieter Annaert and Serge Muyldermans and Nick Devoogdt and Bruno Cogliati and Kwak, {Brenda R.} and Mathieu Vinken",

note = "Funding Information: This work was financially supported by grants of the Fund for Scientific Research-Flanders (FWO-Vlaanderen), the University Hospital of the Vrije Universiteit Brussel-Belgium (Willy Gepts Fonds UZ-Brussel) , the Funda{\c c}{\~a}o de Amparo {\`a} Pesquisa do Estado de S{\~a}o Paulo ( FAPESP - FWO grant 18/10953-9 ) and the FWO / SNSF Lead Agency project funding (SNSF no. 310030E_176050 ). Funding Information: This work was financially supported by grants of the Fund for Scientific Research-Flanders (FWO-Vlaanderen), the University Hospital of the Vrije Universiteit Brussel-Belgium (Willy Gepts Fonds UZ-Brussel), the Funda{\c c}{\~a}o de Amparo {\`a} Pesquisa do Estado de S{\~a}o Paulo (FAPESP-FWO grant 18/10953-9) and the FWO/SNSF Lead Agency project funding (SNSF no. 310030E_176050). Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

year = "2020",

month = jul,

doi = "10.1016/j.pbiomolbio.2020.03.002",

language = "English",

volume = "153",

pages = "35--41",

journal = "Progress in Biophysics and Molecular Biology",

issn = "0079-6107",

publisher = "Elsevier Limited",

}

Non-canonical roles of connexins. / Van Campenhout, Raf ; Cooreman, Axelle; Leroy, Kaat; Rusiecka, Olga Martyna; Van Brantegem, Pieter; Annaert, Pieter; Muyldermans, Serge ; Devoogdt, Nick; Cogliati, Bruno; Kwak, Brenda R.; Vinken, Mathieu.

In: Progress in Biophysics and Molecular Biology, Vol. 153, 07.2020, p. 35-41.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Non-canonical roles of connexins.

AU - Van Campenhout, Raf

AU - Cooreman, Axelle

AU - Leroy, Kaat

AU - Rusiecka, Olga Martyna

AU - Van Brantegem, Pieter

AU - Annaert, Pieter

AU - Muyldermans, Serge

AU - Devoogdt, Nick

AU - Cogliati, Bruno

AU - Kwak, Brenda R.

AU - Vinken, Mathieu

N1 - Funding Information: This work was financially supported by grants of the Fund for Scientific Research-Flanders (FWO-Vlaanderen), the University Hospital of the Vrije Universiteit Brussel-Belgium (Willy Gepts Fonds UZ-Brussel) , the Fundação de Amparo à Pesquisa do Estado de São Paulo ( FAPESP - FWO grant 18/10953-9 ) and the FWO / SNSF Lead Agency project funding (SNSF no. 310030E_176050 ). Funding Information: This work was financially supported by grants of the Fund for Scientific Research-Flanders (FWO-Vlaanderen), the University Hospital of the Vrije Universiteit Brussel-Belgium (Willy Gepts Fonds UZ-Brussel), the Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP-FWO grant 18/10953-9) and the FWO/SNSF Lead Agency project funding (SNSF no. 310030E_176050). Publisher Copyright: © 2020 Elsevier Ltd Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020/7

Y1 - 2020/7

N2 - Gap junctions mediate cellular communication and homeostasis by controlling the intercellular exchange of small and hydrophilic molecules and ions. Gap junction channels are formed by the docking of 2 hemichannels of adjacent cells, which in turn are composed of 6 connexin subunits. Connexin proteins as such can also control the cellular life cycle independent of their channel activities. This has been most demonstrated in the context of cell growth and cell death. Different mechanisms are involved mainly related to direct interaction with cell growth or cell death regulators, but also implying effects on the expression of cell growth and cell death regulators. The present paper focuses on these atypical roles of connexin proteins.

AB - Gap junctions mediate cellular communication and homeostasis by controlling the intercellular exchange of small and hydrophilic molecules and ions. Gap junction channels are formed by the docking of 2 hemichannels of adjacent cells, which in turn are composed of 6 connexin subunits. Connexin proteins as such can also control the cellular life cycle independent of their channel activities. This has been most demonstrated in the context of cell growth and cell death. Different mechanisms are involved mainly related to direct interaction with cell growth or cell death regulators, but also implying effects on the expression of cell growth and cell death regulators. The present paper focuses on these atypical roles of connexin proteins.

KW - connexin

KW - cell growth

KW - cell death

U2 - 10.1016/j.pbiomolbio.2020.03.002

DO - 10.1016/j.pbiomolbio.2020.03.002

M3 - Article

VL - 153

SP - 35

EP - 41

JO - Progress in Biophysics and Molecular Biology

JF - Progress in Biophysics and Molecular Biology

SN - 0079-6107

ER -

Non-canonical roles of connexins.

Abstract

Bibliographical note

Keywords

Access to Document

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Projects

SRP50: SRP-Onderzoekszwaartepunt: Exploiting Peptides: Protein Binders, Modulators and Inhibitors for Imaging and Therapy [Exploit-PeptIT]

OZR2275: Connexin and pannexin channels: function, regulation and applications

FWOSB75: Connexin hemichannels and pannexin channels as mediators and in vitro indicators of drug-induced cholestatic liver injury.

Cite this