Non-channel functions of connexins in cell growth and cell death

Mathieu Vinken, Elke Decrock, Luc Leybaert, Geert Bultynck, Bernard Himpens, Tamara Vanhaecke, Vera Rogiers

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

Cellular communication mediated by gap junction channels and hemichannels, both composed of connexin proteins, constitutes two acknowledged regulatory platforms in the accomplishment of tissue homeostasis. In recent years, an abundance of reports has been published indicating functions for connexin proteins in the control of the cellular life cycle that occur independently of their channel activities. This has yet been most exemplified in the context of cell growth and cell death, and is therefore as such addressed in the current paper. Specific attention is hereby paid to the molecular mechanisms that underpin the cellular non-channel roles of connexin proteins, namely the alteration of the expression of homeostasis determinants and the physical interaction with cell growth and cell death regulators.
Original languageEnglish
Pages (from-to)2002-2008
Number of pages7
JournalBiochimica et Biophysica Acta - Biomembranes
Volume1818
Publication statusPublished - 1 Jun 2012

Keywords

  • connexin
  • cell growth
  • cell death

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