Obstructive and Restrictive Spirometric Patterns: Fixed Cutoffs for FEV1/FEV6 and FEV6

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Abstract

-The purpose of this study was to determine fixed cutoffs for FEV1/FEV6 and FEV6 as an alternative for FEV1/FVC and FVC in the detection of obstructive and restrictive spirometric patterns, respectively.
A total of 11,676 spirometric examinations were analyzed on Caucasian subjects, aged 20-80 yrs.
Receiver operator characteristic curves were used to determine the FEV1/FEV6 ratio and FEV6 value that corresponded to the optimal combination of sensitivity and specificity, compared with the commonly used fixed cutoffs for FEV1/FVC and FVC. Our data indicate that FEV1/FEV6 <73% and FEV6 <82% predicted can be used as a valid alternative for the FEV1/FVC <70% and FVC <80% predicted cutoffs for detection of obstruction and restriction, respectively. A kappa value of 0.87 demonstrates very good overall agreement between the two categorization schemes. For the spirometric diagnosis of airway obstruction (prevalence: 45.9%), FEV1/FEV6 sensitivity was 94.4% and specificity was 93.3%; the positive and negative predictive values were 92.2% and 95.2%, respectively. For the spirometric detection of a restrictive pattern (prevalence 14.9%), FEV6 sensitivity was 95.9% and specificity 98.6%; the positive and negative predictive values were 92.2% and 99.3%, respectively.
Original languageEnglish
Pages (from-to)378-383
Number of pages6
JournalEuropean Respiratory Journal
Volume27
Publication statusPublished - 2006

Bibliographical note

Eur Resp J 2006; 27: 378-383

Keywords

  • chronic obstructive pulmonary disease
  • forced expiratory volume at 6seconds of exhalation
  • pulmonary function testing
  • spirometry

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