OCT Angiography reveals a non-flow area enlargement in the choriocapillaris with increasing age

Pieter Nelis, Viktoria Constanze Mueller, Natasa Mihailovic, Nicole Eter, Marcel ten Tusscher, Maged Alnawaiseh

Research output: Contribution to journalMeeting abstract (Journal)

16 Citations (Scopus)


Purpose : Age is known to influence choriocapillaris (CC) perfusion. To the best of our knowledge, flow signal and non-flow areas have not been evaluated simultaneously in a large population. We performed a retrospective, observational study to evaluate the relationship between age and both non-flow area and flow signal in the choriocapillaris of the macular region, as measured using optical coherence tomography angiography (OCTA).

Methods : 87 eyes of 87 healthy volunteers were examined using a high-speed and high-resolution spectral-domain OCT XR Avanti system with a split-spectrum amplitude de-correlation angiography algorithm. Choriocapillaris images were analysed to determine the choriocapillaris decorrelation index (CCDI), flow voids greater than 10,000 µm2 (FV10000) and signal voids greater than 40,000 µm2 (FV40000).

Results : The mean patient age was 30.55 ± 14.59 years. Mean CCDI was 116.40
± 5.64, mean FV10000 65.85% ± 7.75 and mean FV40000% 36.87 ± 15.04. Correlations between age and respectively CCDI, FV10000 and FV40000 showed a moderate but significant correlation (r = -0.3545, p = 0.0008;r = 0.3626, p = 0.0006; r =0.3897, p = 0.0002).

Conclusions : Our results suggest an enlargment of non-flow areas with increasing age, which could explain the decrease in overall flow signal.
Original languageEnglish
Pages (from-to)3054-3054
JournalInvestigative Ophthalmology & Visual Science
Issue number9
Publication statusPublished - Jul 2019
EventAnnual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO) - Vancouver, Canada
Duration: 28 Apr 20192 May 2019


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