Ocular Surface Homeostasis After Scleral Lens Usage

Brice Ballet, Josephine Agnes Behaegel, Reppe Sjur, Alejandra Consejo, Hans Christian Aass, Tor Paaske Utheim, Carina Koppen, Sorcha Ní Dhubhghaill

Research output: Contribution to journalArticlepeer-review


Objectives:The aim of this prospective study is to examine the effects of 5 hours of well-fitted, mini-scleral contact lens (mini-SL) wear on the tear film cytokine expression in healthy eyes.Methods:Twenty-three healthy participants were included in the study. One eye of each participant was selected at random, and a mini-SL measuring 16.5 mm in diameter was fitted by an experienced contact lens specialist. The contact lens remained in place for 5 hours. Precorneal tear fluid was collected using capillary tubes at three different time points: baseline before SL insertion (T0), after 5 hours of SL wear (T1), and 3 hours after SL removal (T2). The concentration of 40 inflammatory cytokines at the three different time points was determined using multiplex bead assay.Results:Mini-scleral lens wear did not result in significant changes in the cytokine-to-protein ratio after 5 hours of wear on a healthy eye.Conclusions:Although a well-fitted mini-SL reduces the rate at which the precorneal tear film is refreshed, 5 hours of lens wear did not appear to significantly affect the tears cytokine-to-protein ratio, suggesting that scleral lenses have minimal impact on corneal cytokine expression.

Original languageEnglish
Pages (from-to)459-463
Number of pages5
JournalEye & Contact Lens
Issue number11
Publication statusPublished - 1 Nov 2023

Bibliographical note

Funding Information:
This study was realized by a Fund for Research in Ophthalmology (FRO) grant. The authors thank Microlens Contactlens Technology b.v. (Arnhem, the Netherlands) and Maarten Van Hoey for providing and fitting the contact lenses used in this study.

Publisher Copyright:
© 2023 Lippincott Williams and Wilkins. All rights reserved.


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