One-Year Follow-Up after Single Procedure Cryoballoon Ablation: A Comparison between the First and Second Generation Balloon.

G. Di Giovanni, Kristel Wauters, Jean-Baptiste Chierchia, J. Sieira, M. Levinstein, G. Conte, Carlo De Asmundis, G. Baltogiannis, Y. Saitoh, G. Ciconte, J. Julia, G. Mugnai, G. Irfan, Pedro Brugada

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142 Citations (Scopus)

Abstract

BACKGROUND:

With respect to the first generation Cryoballoon (CB), the second generation (Cryoballoon Advance; Medtronic, USA; CB-A) was designed with technical modifications resulting in a larger and more uniform zone of freezing on the balloons surface aiming at procedural outcome improvement in the setting of atrial fibrillation (AF) ablation. However a comparison between both technologies on a midterm follow-up is missing in today's literature.

METHODS:

A total of 100 patients (the last 50 patients with the 1st generation CB and the first 50 patients with the 2nd generation CB-A upon its inception in our center) having undergone a single CB ablation for paroxysmal AF (PAF) and having completed a 12-month follow-up were consecutively included in our study. Freedom from AF off-antiarrhythmic drugs (AAD) after a single procedure was 78% (39/50) in CB-A and 58% (29/50) in the CB group (p = 0.03) during the whole follow-up duration. Considering a blanking period of 3 months, freedom from AF off-AAD was achieved in 84% (42/50) in CB-A, while 66% (33/50) were free from recurrence in the CB group (p = 0.038). Right phrenic nerve palsy (PNP) occurred in 8 patients (16%) in CB-A group and in 4 patients (8%) in the CB group.

CONCLUSION:

Freedom from AF on 12 months follow-up was significantly higher in the CB-A group with respect to the first generation device. The most frequent complication observed was PNP.
Original languageEnglish
Pages (from-to)834-839
Number of pages6
JournalJournal of Cardiovascular Electrophysiology
Volume25
Issue number8
Publication statusPublished - Aug 2014

Keywords

  • atrial fibrillation
  • catheter ablation
  • cryoballoon
  • phrenic nerve
  • pulmonary vein isolation

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