Optimization of SeDeM Diagram Expert System: Improved Cohesion Index's (Icd) Methodology.

Isaac Nofrerias, Anna Nardi, Marc Suñé-Pou, Joost Boeckmans, Josep Maria Suñé-Negre, Encarna García-Montoya, Pilar Pérez-Lozano, Josep Ramón Ticó-Grau, Montserrat Miñarro-Carmona

Research output: Contribution to journalArticle


In this study, we suggest optimizing the methodology to determine the Cohesion Index (Icd) in order to avoid mistaken characterizations due to powder bulk density. For this purpose, five different excipients, with different bulk densities and of different chemical nature, were compressed at different heights. Their compression and their tablet characterization enable establishing a powder weight for compression in accordance with its bulk density. Therefore, the resulting tablet will have a height within a defined range of heights where it has no critical effects on its hardness. Then, the impact of this optimization is shown in a formula development, one of the main SeDeM's applications. A mathematical equation was used to calculate the theoretical amount of excipient to formulate the API according to both methodologies. The compression results demonstrate that the characterization with the NM-Icd is more accurate than the previous one while preserving its simplicity.
Original languageEnglish
Article numbere0203846
Number of pages18
JournalPLoS ONE
Issue number9
Publication statusPublished - Sep 2018

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