Optimizing antimicrobial efficacy at minimal toxicity: A novel indication for continuous renal replacement therapy?

Patrick Honoré, Rita Jacobs, Herbert Spapen

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Continuous renal replacement therapy (CRRT) has become a standard adjuvant therapy in the intensive care unit (ICU). Apart from commonly accepted indications, such as acute kidney injury (AKI) of different origins, hemodynamic instability without AKI and fluid overload, CRRT can act as a ‘supportive’ therapy that allows adequate dosing of antimicrobials whilst limiting some or all of their known toxicities. In particular, CRRT may elegantly reconcile optimal treatment efficacy and safety when high doses of antimicrobial agents have to be administered for an extended time period [1, 2]. In this chapter, we briefly review the literature and share our own experience regarding some antibiotics and antifungals when this ‘novel’ CRRT approach is realized.
Original languageEnglish
Title of host publicationAnnual Update in Intensive Care and Emergency Medicine 2015
EditorsJ-L Vincent
PublisherSpringer International Publishing
Pages43-52
ISBN (Print)978-3-319-13760-5
Publication statusPublished - 2015

Keywords

  • Acute Kidney Injury
  • Continuous Renal Replacement Therapy
  • Adsorptive Membrane
  • High Maintenance Dose
  • Standard Adjuvant Therapy

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