Oxygenation and Membrane Oxygenators: Emergence, Evolution and Progress in Material Development and Process Enhancement for Biomedical Applications

Amir Hossein Mostafavi, Ajay Kumar Mishra, Mathias Ulbricht, Joeri F.M. Denayer, Seyed Saeid Hosseini

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)
21 Downloads (Pure)


Ever-increasing demands for high performance blood oxygenators have led to continuous advancements in this field. Despite the progresses made since their emergence, there still exist challenges that intimidate the reliability of membrane oxygenators. A promising approach for addressing these challenges and enhancing the overall process performance relates to the selection, development, and modification of materials with desirable characteristics. The main impetus for the present review is to bring forward important and yet less explored subjects by shedding light on the technological, design, and engineering aspects of oxygenators and the oxygenation process. Special attention is paid to membrane oxygenators and their essential characteristics such as gas transport, plasma leakage, and biocompatibility. Also, various practical configurations of membrane oxygenators are illustrated with their merits and limitations. From the materials perspective, a comprehensive range of polymeric materials with track records for applications as membrane oxygenators are surveyed and analyzed considering their physicochemical and biocompatibility properties in order to gain insights into the features of an optimal material. In addition to elaborations on the methods for fabrication of membrane oxygenators, various effective techniques that could be used for altering the microstructure and surface properties of the membranes are presented. Also, an in-depth overview is provided about the transport phenomena in membrane oxygenators aiming to provide a better understanding of the molecular and process aspects of the process. An overview of the state of the art is summarized along with points about the trends of future developments are provided at the end.
Original languageEnglish
Pages (from-to)230-259
Number of pages30
JournalJournal of Membrane Science & Research
Issue number4
Publication statusPublished - Oct 2021

Bibliographical note

Publisher Copyright:
© 2021 Amirkabir University of Technology - Membrane Processes Research Laboratory. All rights reserved.

Copyright 2022 Elsevier B.V., All rights reserved.


  • Membrane oxygenator
  • Oxygenation process
  • Membrane materials
  • Gas exchange
  • Transport phenomena


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