Pannexin1 as mediator of inflammation and cell death

Sara Crespo Yanguas, Joost Willebrords, Scott R. Johnstone, Michaël Maes, Elke Decrock, Marijke De Bock, Luc Leybaert, Bruno Cogliati, Mathieu Vinken

Research output: Contribution to journalArticlepeer-review

70 Citations (Scopus)

Abstract

Pannexins form channels at the plasma membrane surface that establish a pathway for communication between the cytosol of individual cells and their extracellular environment. By doing so, pannexin signaling dictates several physiological functions, but equally underlies a number of pathological processes. Indeed, pannexin channels drive inflammation by assisting in the activation of inflammasomes, the release of pro-inflammatory cytokines, and the activation and migration of leukocytes. Furthermore, these cellular pores facilitate cell death, including apoptosis, pyroptosis and autophagy. The present paper reviews the roles of pannexin channels in inflammation and cell death. In a first part, a state-of-the-art overview of pannexin channel structure, regulation and function is provided. In a second part, the mechanisms behind their involvement in inflammation and cell death are discussed.
Original languageEnglish
Pages (from-to)51-61
Number of pages11
JournalBiochemica et Biophysica Acta - Molecular Cell Research
Volume1864
Issue number1
DOIs
Publication statusPublished - 2017

Bibliographical note

Copyright © 2016 Elsevier B.V. All rights reserved.

Keywords

  • Apoptosis
  • Autophagy
  • Inflammation
  • Pannexin
  • Pyroptosis
  • Inflammasomes/immunology
  • Cytosol/immunology
  • Signal Transduction
  • Humans
  • Gene Expression Regulation
  • Cell Death/genetics
  • Animals
  • Nerve Tissue Proteins/chemistry
  • Inflammation/genetics
  • Cell Membrane/immunology
  • Connexins/chemistry
  • Cytokines/biosynthesis
  • Cell Movement
  • Leukocytes/immunology

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