Pannexin1 proteins form communication channels at the cell plasma membrane surface, which allow the transfer of small molecules and ions between the intracellular compartment and extracellular environment. In this way, pannexin1 channels play an important role in various cellular processes and diseases. Indeed, a plethora of human pathologies is associated with the activation of pannexin1 channels. The present paper reviews and summarizes the structure, life cycle, regulation and (patho)physiological roles of pannexin1 channels, with a particular focus on the relevance of pannexin1 channels in liver diseases.
Original languageEnglish
Article number1220405
Number of pages14
JournalFrontiers in cell and developmental biology
Publication statusPublished - 25 Jul 2023

Bibliographical note

Funding Information:
This work was financially supported by the European Future and Emerging Technologies program (grant 858014 “PANACHE”), the Fund for Scientific Research Research-Flanders, the University Hospital of the Vrije Universiteit Brussel-Belgium (“Willy Gepts Fonds” UZ-VUB) and the Methusalem program of the Flemish government-Belgium.

Publisher Copyright:
Copyright © 2023 Van Campenhout, Caufriez, Tabernilla, Maerten, De Boever, Sanz-Serrano, Kadam and Vinken.

Copyright 2023 Elsevier B.V., All rights reserved.


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