Pannexin1 channels in the liver: an open enemy.

Raf Van Campenhout; Anne Caufriez; Andres Tabernilla Garcia; Amy Maerten; Sybren De Boever; Julen Sanz-Serrano; Prashant Kadam; Mathieu Vinken

doi:10.3389/fcell.2023.1220405

Pannexin1 channels in the liver: an open enemy.

Raf Van Campenhout, Anne Caufriez, Andres Tabernilla Garcia, Amy Maerten, Sybren De Boever, Julen Sanz-Serrano, Prashant Kadam, Mathieu Vinken

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

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Abstract

Pannexin1 proteins form communication channels at the cell plasma membrane surface, which allow the transfer of small molecules and ions between the intracellular compartment and extracellular environment. In this way, pannexin1 channels play an important role in various cellular processes and diseases. Indeed, a plethora of human pathologies is associated with the activation of pannexin1 channels. The present paper reviews and summarizes the structure, life cycle, regulation and (patho)physiological roles of pannexin1 channels, with a particular focus on the relevance of pannexin1 channels in liver diseases.

Original language	English
Article number	1220405
Number of pages	14
Journal	Frontiers in cell and developmental biology
Volume	11
DOIs	https://doi.org/10.3389/fcell.2023.1220405
Publication status	Published - 25 Jul 2023

Bibliographical note

Funding Information:
This work was financially supported by the European Future and Emerging Technologies program (grant 858014 “PANACHE”), the Fund for Scientific Research Research-Flanders, the University Hospital of the Vrije Universiteit Brussel-Belgium (“Willy Gepts Fonds” UZ-VUB) and the Methusalem program of the Flemish government-Belgium.

Publisher Copyright:
Copyright © 2023 Van Campenhout, Caufriez, Tabernilla, Maerten, De Boever, Sanz-Serrano, Kadam and Vinken.

Copyright:
Copyright 2023 Elsevier B.V., All rights reserved.

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10.3389/fcell.2023.1220405Licence: CC BY

paperFinal published version, 1.92 MBLicence: CC BY

Cite this

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title = "Pannexin1 channels in the liver: an open enemy.",

abstract = "Pannexin1 proteins form communication channels at the cell plasma membrane surface, which allow the transfer of small molecules and ions between the intracellular compartment and extracellular environment. In this way, pannexin1 channels play an important role in various cellular processes and diseases. Indeed, a plethora of human pathologies is associated with the activation of pannexin1 channels. The present paper reviews and summarizes the structure, life cycle, regulation and (patho)physiological roles of pannexin1 channels, with a particular focus on the relevance of pannexin1 channels in liver diseases.",

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AU - Van Campenhout, Raf

AU - Caufriez, Anne

AU - Tabernilla Garcia, Andres

AU - Maerten, Amy

AU - De Boever, Sybren

AU - Sanz-Serrano, Julen

AU - Kadam, Prashant

AU - Vinken, Mathieu

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PY - 2023/7/25

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N2 - Pannexin1 proteins form communication channels at the cell plasma membrane surface, which allow the transfer of small molecules and ions between the intracellular compartment and extracellular environment. In this way, pannexin1 channels play an important role in various cellular processes and diseases. Indeed, a plethora of human pathologies is associated with the activation of pannexin1 channels. The present paper reviews and summarizes the structure, life cycle, regulation and (patho)physiological roles of pannexin1 channels, with a particular focus on the relevance of pannexin1 channels in liver diseases.

AB - Pannexin1 proteins form communication channels at the cell plasma membrane surface, which allow the transfer of small molecules and ions between the intracellular compartment and extracellular environment. In this way, pannexin1 channels play an important role in various cellular processes and diseases. Indeed, a plethora of human pathologies is associated with the activation of pannexin1 channels. The present paper reviews and summarizes the structure, life cycle, regulation and (patho)physiological roles of pannexin1 channels, with a particular focus on the relevance of pannexin1 channels in liver diseases.

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Pannexin1 channels in the liver: an open enemy.

Abstract

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FWOAL1070: The role of pannexin1 channels in non-alcoholic steatohepatitis: therapeutic and diagnostic relevance.

FWOAL879: Nanobody-based inhibitors of connexin hemichannels and pannexin channels as novel therapeutics for the treatment of inflammatory hepatic and cardiovascular diseases.

FWOAL887: Are connexin hemichannels and pannexin channels therapeutic drug targets and diagnostic biomarkers in cholestasis?

Cite this

Pannexin1 channels in the liver: an open enemy.

Abstract

Bibliographical note

Access to Document

Other files and links

Fingerprint

Projects

FWOAL1070: The role of pannexin1 channels in non-alcoholic steatohepatitis: therapeutic and diagnostic relevance.

FWOAL879: Nanobody-based inhibitors of connexin hemichannels and pannexin channels as novel therapeutics for the treatment of inflammatory hepatic and cardiovascular diseases.

FWOAL887: Are connexin hemichannels and pannexin channels therapeutic drug targets and diagnostic biomarkers in cholestasis?

Cite this