Parity and secondary progression in multiple sclerosis.

M Koch; M Uyttenboogaart; D.j. Heersema; C. Steen; Jacques De Keyser

Parity and secondary progression in multiple sclerosis.

M Koch, M Uyttenboogaart, D.j. Heersema, C. Steen, Jacques De Keyser

Gerontology

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63 Citations (Scopus)

Abstract

Pregnancy has a well-documented effect on relapses in multiple sclerosis (MS), whereas little is known about the impact of pregnancy and childbirth on the risk of secondary progression. OBJECTIVE: To investigate the association of parity and secondary progression in women with MS. METHODS: The association of the number of births and secondary progression was studied in a hospital-based cohort of 277 women with MS. Data were analysed in a multivariable logistic regression model, with adjustment for possible confounders. RESULTS: Parity was not independently associated with secondary progression, while the factors disease duration (OR per year increase: 1.05, 95% CI 1.03 to 1.09) and use of immunomodulatory treatments (OR 0.23, 95% CI 0.08 to 0.65) were independently associated with secondary progression. CONCLUSION: We found no evidence that parity influences the risk of secondary progression in MS. Further population-based studies on the association of pregnancy and childbirth on the long-term prognosis of MS are needed.

Original language	English
Pages (from-to)	676-678
Number of pages	3
Journal	J Neurol Neurosurg Psychiatry
Volume	80
Issue number	6
Publication status	Published - Jun 2009

Keywords

pregnancy

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http://www.ncbi.nlm.nih.gov/pubmed/19448093?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=9

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title = "Parity and secondary progression in multiple sclerosis.",

abstract = "Pregnancy has a well-documented effect on relapses in multiple sclerosis (MS), whereas little is known about the impact of pregnancy and childbirth on the risk of secondary progression. OBJECTIVE: To investigate the association of parity and secondary progression in women with MS. METHODS: The association of the number of births and secondary progression was studied in a hospital-based cohort of 277 women with MS. Data were analysed in a multivariable logistic regression model, with adjustment for possible confounders. RESULTS: Parity was not independently associated with secondary progression, while the factors disease duration (OR per year increase: 1.05, 95% CI 1.03 to 1.09) and use of immunomodulatory treatments (OR 0.23, 95% CI 0.08 to 0.65) were independently associated with secondary progression. CONCLUSION: We found no evidence that parity influences the risk of secondary progression in MS. Further population-based studies on the association of pregnancy and childbirth on the long-term prognosis of MS are needed.",

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author = "M Koch and M Uyttenboogaart and D.j. Heersema and C. Steen and {De Keyser}, Jacques",

year = "2009",

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language = "English",

volume = "80",

pages = "676--678",

journal = "Journal of Neurology, Neurosurgery and Psychiatry",

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TY - JOUR

T1 - Parity and secondary progression in multiple sclerosis.

AU - Koch, M

AU - Uyttenboogaart, M

AU - Heersema, D.j.

AU - Steen, C.

AU - De Keyser, Jacques

PY - 2009/6

Y1 - 2009/6

N2 - Pregnancy has a well-documented effect on relapses in multiple sclerosis (MS), whereas little is known about the impact of pregnancy and childbirth on the risk of secondary progression. OBJECTIVE: To investigate the association of parity and secondary progression in women with MS. METHODS: The association of the number of births and secondary progression was studied in a hospital-based cohort of 277 women with MS. Data were analysed in a multivariable logistic regression model, with adjustment for possible confounders. RESULTS: Parity was not independently associated with secondary progression, while the factors disease duration (OR per year increase: 1.05, 95% CI 1.03 to 1.09) and use of immunomodulatory treatments (OR 0.23, 95% CI 0.08 to 0.65) were independently associated with secondary progression. CONCLUSION: We found no evidence that parity influences the risk of secondary progression in MS. Further population-based studies on the association of pregnancy and childbirth on the long-term prognosis of MS are needed.

AB - Pregnancy has a well-documented effect on relapses in multiple sclerosis (MS), whereas little is known about the impact of pregnancy and childbirth on the risk of secondary progression. OBJECTIVE: To investigate the association of parity and secondary progression in women with MS. METHODS: The association of the number of births and secondary progression was studied in a hospital-based cohort of 277 women with MS. Data were analysed in a multivariable logistic regression model, with adjustment for possible confounders. RESULTS: Parity was not independently associated with secondary progression, while the factors disease duration (OR per year increase: 1.05, 95% CI 1.03 to 1.09) and use of immunomodulatory treatments (OR 0.23, 95% CI 0.08 to 0.65) were independently associated with secondary progression. CONCLUSION: We found no evidence that parity influences the risk of secondary progression in MS. Further population-based studies on the association of pregnancy and childbirth on the long-term prognosis of MS are needed.

KW - pregnancy

M3 - Article

VL - 80

SP - 676

EP - 678

JO - Journal of Neurology, Neurosurgery and Psychiatry

JF - Journal of Neurology, Neurosurgery and Psychiatry

SN - 0022-3050

IS - 6

ER -

Parity and secondary progression in multiple sclerosis.

Abstract

Keywords

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