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Abstract: Introduction: Radiolabeled bombesin (BN) conjugates are promising radiotracers for imaging and therapy of breast and prostate tumors in which BN2-gastrin-releasing peptide (GRP) receptors are overexpressed. However, the low in vivo stability of BN conjugates may limit their clinical application. In an attempt to improve their pharmacokinetics and counteract their rapid enzymatic degradation, we prepared a series of polyethylene glycol (PEG)-ylated BN(7-14) analogues for radiolabeling with Tc-99m(CO)(3) and evaluated them in vitro and in vivo.
|Number of pages||13|
|Journal||Nuclear Medicine and Biology|
|Publication status||Published - Oct 2011|
- Gastrin-releasing peptide receptor
- SPECT/CT imaging
- Prostate cancer
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