PEGylation of Tc-99m-labeled bombesin analogues improves their pharmacokinetic properties

S. Daepp, Elisa Garcia-Garayoa, Veronique Maes, Luc Brans, Dirk Tourwe, Muller Christina, R. Schibli

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)


Abstract: Introduction: Radiolabeled bombesin (BN) conjugates are promising radiotracers for imaging and therapy of breast and prostate tumors in which BN2-gastrin-releasing peptide (GRP) receptors are overexpressed. However, the low in vivo stability of BN conjugates may limit their clinical application. In an attempt to improve their pharmacokinetics and counteract their rapid enzymatic degradation, we prepared a series of polyethylene glycol (PEG)-ylated BN(7-14) analogues for radiolabeling with Tc-99m(CO)(3) and evaluated them in vitro and in vivo.
Original languageEnglish
Pages (from-to)997-1009
Number of pages13
JournalNuclear Medicine and Biology
Issue number7
Publication statusPublished - Oct 2011


  • Gastrin-releasing peptide receptor
  • bombesin
  • Technetium-99m
  • SPECT/CT imaging
  • PEGylation
  • Prostate cancer


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