Peroxiredoxins wear many hats: Factors that fashion their peroxide sensing personalities

Research output: Contribution to journalScientific review

Abstract

Peroxiredoxins (Prdxs) sense and assess peroxide levels, and signal through protein interactions. Understanding the role of the multiple structural and post-translational modification (PTM) layers that tunes the peroxiredoxin specificities is still a challenge. In this review, we give a tabulated overview on what is known about human and bacterial peroxiredoxins with a focus on structure, PTMs, and protein-protein interactions. Armed with numerous cellular and atomic level experimental techniques, we look at the future and ask ourselves what is still needed to give us a clearer view on the cellular operating power of Prdxs in both stress and nonstress conditions.
Original languageEnglish
Article number101959
Number of pages50
JournalRedox Biology
Publication statusAccepted/In press - 2021

Keywords

  • peroxiredoxin
  • redox biology
  • post-translational modification (PTM)
  • hydrogen peroxide (H2O2)
  • protein-protein interactions (PPI)
  • Prx
  • Prdx

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