Peroxiredoxins wear many hats: Factors that fashion their peroxide sensing personalities

Jesalyn Bolduc; Katarina Koruza; Ting Luo; Julia Malo Pueyo; Trung Nghia Vo; Daria Ezeriņa; Joris Messens

doi:10.1016/j.redox.2021.101959

Peroxiredoxins wear many hats: Factors that fashion their peroxide sensing personalities

Jesalyn Bolduc, Katarina Koruza, Ting Luo, Julia Malo Pueyo, Trung Nghia Vo, Daria Ezeriņa, Joris Messens

Research output: Contribution to journal › Scientific review › peer-review

52 Citations (Scopus)

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Abstract

Peroxiredoxins (Prdxs) sense and assess peroxide levels, and signal through protein interactions. Understanding the role of the multiple structural and post-translational modification (PTM) layers that tunes the peroxiredoxin specificities is still a challenge. In this review, we give a tabulated overview on what is known about human and bacterial peroxiredoxins with a focus on structure, PTMs, and protein-protein interactions. Armed with numerous cellular and atomic level experimental techniques, we look at the future and ask ourselves what is still needed to give us a clearer view on the cellular operating power of Prdxs in both stress and non-stress conditions.

Original language	English
Article number	101959
Number of pages	17
Journal	Redox Biology
Volume	42
DOIs	https://doi.org/10.1016/j.redox.2021.101959
Publication status	Published - Jun 2021

Bibliographical note

Funding Information:
This work was funded with a VIB grant (to J.M.), and the Research Foundation-Flanders –Fonds de la Recherche Scientifique Excellence of Science project no. 30829584 (to J.M). Ting L. was supported with a Chinese Scholarship Council grant (File No. 201707650018 ).

Funding Information:
This work was funded with a VIB grant (to J.M.), and the Research Foundation-Flanders?Fonds de la Recherche Scientifique Excellence of Science project no. 30829584 (to J.M). Ting L. was supported with a Chinese Scholarship Council grant (File No. 201707650018).

Publisher Copyright:
© 2021 The Author(s)

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Peroxiredoxins wear many hats Factors that fashion their peroxide sensing personalitiesFinal published version, 2.98 MBLicence: CC BY-NC-ND

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title = "Peroxiredoxins wear many hats: Factors that fashion their peroxide sensing personalities",

abstract = "Peroxiredoxins (Prdxs) sense and assess peroxide levels, and signal through protein interactions. Understanding the role of the multiple structural and post-translational modification (PTM) layers that tunes the peroxiredoxin specificities is still a challenge. In this review, we give a tabulated overview on what is known about human and bacterial peroxiredoxins with a focus on structure, PTMs, and protein-protein interactions. Armed with numerous cellular and atomic level experimental techniques, we look at the future and ask ourselves what is still needed to give us a clearer view on the cellular operating power of Prdxs in both stress and non-stress conditions.",

author = "Jesalyn Bolduc and Katarina Koruza and Ting Luo and {Malo Pueyo}, Julia and Vo, {Trung Nghia} and Daria Ezeriņa and Joris Messens",

note = "Funding Information: This work was funded with a VIB grant (to J.M.), and the Research Foundation-Flanders –Fonds de la Recherche Scientifique Excellence of Science project no. 30829584 (to J.M). Ting L. was supported with a Chinese Scholarship Council grant (File No. 201707650018 ). Funding Information: This work was funded with a VIB grant (to J.M.), and the Research Foundation-Flanders?Fonds de la Recherche Scientifique Excellence of Science project no. 30829584 (to J.M). Ting L. was supported with a Chinese Scholarship Council grant (File No. 201707650018). Publisher Copyright: {\textcopyright} 2021 The Author(s)",

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AU - Bolduc, Jesalyn

AU - Koruza, Katarina

AU - Luo, Ting

AU - Malo Pueyo, Julia

AU - Vo, Trung Nghia

AU - Ezeriņa, Daria

AU - Messens, Joris

N1 - Funding Information: This work was funded with a VIB grant (to J.M.), and the Research Foundation-Flanders –Fonds de la Recherche Scientifique Excellence of Science project no. 30829584 (to J.M). Ting L. was supported with a Chinese Scholarship Council grant (File No. 201707650018 ). Funding Information: This work was funded with a VIB grant (to J.M.), and the Research Foundation-Flanders?Fonds de la Recherche Scientifique Excellence of Science project no. 30829584 (to J.M). Ting L. was supported with a Chinese Scholarship Council grant (File No. 201707650018). Publisher Copyright: © 2021 The Author(s)

PY - 2021/6

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N2 - Peroxiredoxins (Prdxs) sense and assess peroxide levels, and signal through protein interactions. Understanding the role of the multiple structural and post-translational modification (PTM) layers that tunes the peroxiredoxin specificities is still a challenge. In this review, we give a tabulated overview on what is known about human and bacterial peroxiredoxins with a focus on structure, PTMs, and protein-protein interactions. Armed with numerous cellular and atomic level experimental techniques, we look at the future and ask ourselves what is still needed to give us a clearer view on the cellular operating power of Prdxs in both stress and non-stress conditions.

AB - Peroxiredoxins (Prdxs) sense and assess peroxide levels, and signal through protein interactions. Understanding the role of the multiple structural and post-translational modification (PTM) layers that tunes the peroxiredoxin specificities is still a challenge. In this review, we give a tabulated overview on what is known about human and bacterial peroxiredoxins with a focus on structure, PTMs, and protein-protein interactions. Armed with numerous cellular and atomic level experimental techniques, we look at the future and ask ourselves what is still needed to give us a clearer view on the cellular operating power of Prdxs in both stress and non-stress conditions.

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JO - Redox Biology

JF - Redox Biology

SN - 2213-2317

M1 - 101959

ER -

Peroxiredoxins wear many hats: Factors that fashion their peroxide sensing personalities

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