Peroxiredoxins wear many hats: Factors that fashion their peroxide sensing personalities

Research output: Contribution to journalArticle

Abstract

Peroxiredoxins (Prdxs) sense and assess peroxide levels, and signal through protein interactions. Understanding the role of the multiple structural and post-translational modification (PTM) layers that tunes the peroxiredoxin specificities is still a challenge. In this review, we give a tabulated overview on what is known about human and bacterial peroxiredoxins with a focus on structure, PTMs, and protein-protein interactions. Armed with numerous cellular and atomic level experimental techniques, we look at the future and ask ourselves what is still needed to give us a clearer view on the cellular operating power of Prdxs in both stress and non-stress conditions.

Original languageEnglish
Article number101959
Number of pages17
JournalRedox Biology
Volume42
DOIs
Publication statusPublished - Jun 2021

Fingerprint

Dive into the research topics of 'Peroxiredoxins wear many hats: Factors that fashion their peroxide sensing personalities'. Together they form a unique fingerprint.

Cite this