Persistence of Phrenic Nerve Palsy Following 28 mm Cryoballoon Ablation: A Four Year Single Center Experience

Yukio Saitoh, Ghazala Irfan, Giuseppe Ciconte, Giacomo Mugnai, Juan Sieira, Giacomo Di Giovanni, Giannis Baltogiannis, Giulio Conte, Burak Hünük, Erwin Ströker, Vedran Velagić, Overeinder Ingrid, Carlo de Asmundis, Jean-Baptiste Chierchia, Pedro Brugada

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Abstract

BACKGROUND: Phrenic nerve palsy (PNP) is the most frequently observed complication in the setting of cryoballoon (CB) ablation (Arctic Front, Medtronic, MN). Although, usually transient, resolving before the end of the procedure, persistent PNP (not resolving before the end of procedure) can occur. Literature on persistent PNP after second generation CB ablation is relatively sparse.

METHODS: A total of 316 consecutive patients having undergone large 28mm CB ablation as index procedure in the Heart Rhythm Management Center, UZ Brussels, Belgium from January 2009 to December 2013 were retrospectively reviewed for the study. Of these 117 patients were treated with the first generation CB (CB1) and 199 patients with the second generation CB (CB2).

RESULTS: PNP occurred in 10% of the total population. Persistent PNP was only observed following CB2 ablation which occurred in 4.5% of the group. At a mean follow up of 11 months, diaphragmatic contraction in persistent PNP patients resumed in 78% (7/9) of the patients. In a final follow up at 5 and 20 months, PNP persisted in two patients respectively. Phrenic nerve palsy during ablation in the RIPV was only observed in the CB2 group. No predictors of persistency of PNP were observed.

CONCLUSION: Persistence of PNP only occurred in the CB2 group in 4.5% of patients. The majority of patients with persistent PNP were asymptomatic. In most of the patients having persistent PNP after ablation, complete phrenic nerve function resumed during follow up (78%). This article is protected by copyright. All rights reserved.

Original languageEnglish
Pages (from-to)807-814
Number of pages8
JournalPACE - Pacing and Clinical Electrophysiology
Volume38
Issue number7
Early online date7 Apr 2015
DOIs
Publication statusPublished - Jul 2015

Bibliographical note

This article is protected by copyright. All rights reserved.

Keywords

  • Ablation
  • Atrial FibrillationAtrial Fibrillation
  • Cryoballoon
  • Phrenic Nerve Palsy

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