PMMA-silica nanocomposite coating: Effective corrosion protection and biocompatibility for a Ti6Al4V alloy

Samarah V. Harb; Mayara C. Uvida; Andressa Trentin; Anderson O. Lobo; Thomas Webster; Sandra H. Pulcinelli; Celso V. Santilli; Peter Hammer

doi:10.1016/j.msec.2020.110713

PMMA-silica nanocomposite coating: Effective corrosion protection and biocompatibility for a Ti6Al4V alloy

Samarah V. Harb, Mayara C. Uvida, Andressa Trentin, Anderson O. Lobo, Thomas Webster, Sandra H. Pulcinelli, Celso V. Santilli, Peter Hammer

Materials and Chemistry

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Ti6Al4V is the mostly applied metallic alloy for orthopedic and dental implants, however, its lack of osseoin- tegration and poor long-term corrosion resistance often leads to a secondary surgical intervention, recovery delay and toxicity to the surrounding tissue. As a potential solution of these issues poly(methyl methacrylate)- silicon dioxide (PMMA-silica) coatings have been applied on a Ti6Al4V alloy to act simultaneously as an an- ticorrosive barrier and bioactive film. The nanocomposite, composed of PMMA covalently bonded to the silica phase through 3-(trimethoxysilyl)propyl methacrylate (MPTS), has been synthesized combining the sol-gel process with radical polymerization of methyl methacrylate. The 5 μm thick coatings deposited on Ti6Al4V have a smooth surface, are homogeneous, transparent, free of pores and cracks, and show a strong adhesion to the metallic substrate (11.6 MPa). Electrochemical impedance spectroscopy results proved an excellent anticorrosive performance of the coating, with an impedance modulus of 26 GΩ cm2 and long-term durability in simulated body fluid (SBF) solution. Moreover, after 21 days of immersion in SBF, the PMMA-silica coating presented apatite crystal deposits, which suggests in vivo bone bioactivity. This was confirmed by biological character- ization showing enhanced osteoblast proliferation, explained by the increased surface free energy and protein adsorption. The obtained results suggest that PMMA-silica hybrids can act in a dual role as efficient anticorrosive and bioactive coating for Ti6Al4V alloys

Original language	English
Article number	110713
Number of pages	11
Journal	Materials Science and Engineering: A
Volume	110
DOIs	https://doi.org/10.1016/j.msec.2020.110713
Publication status	Published - May 2020

Bibliographical note

Funding Information:
This work was supported by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Samarah V. Harb and Andressa Trentin have received scholarships, process No. 2015/09342-7 and 2015/11907-2, respectively, from FAPESP, and Mayara C. Uvida has received a scholarship from INCT Tecnologias Ecoeficientes Avançadas em Produtos Cimentícios Advanced Eco-efficient Cement-Based Technologies – CEMtec Capes process 88887.136401/2017-00 CAPES - Finance Code 001. Anderson O. Lobo acknowledges the CNPq (# 303752/2017-3 ) for financial support.

Publisher Copyright:
© 2020 Elsevier B.V.

Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.

Keywords

Organic-inorganic coating
Corrosion protection
Biomaterial
Bioactive coating
Ti6Al4V alloy
PMMA-silica hybrid

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10.1016/j.msec.2020.110713

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@article{59f8438f615a422abb32125f2cf4b489,

title = "PMMA-silica nanocomposite coating: Effective corrosion protection and biocompatibility for a Ti6Al4V alloy",

abstract = "Ti6Al4V is the mostly applied metallic alloy for orthopedic and dental implants, however, its lack of osseoin- tegration and poor long-term corrosion resistance often leads to a secondary surgical intervention, recovery delay and toxicity to the surrounding tissue. As a potential solution of these issues poly(methyl methacrylate)- silicon dioxide (PMMA-silica) coatings have been applied on a Ti6Al4V alloy to act simultaneously as an an- ticorrosive barrier and bioactive film. The nanocomposite, composed of PMMA covalently bonded to the silica phase through 3-(trimethoxysilyl)propyl methacrylate (MPTS), has been synthesized combining the sol-gel process with radical polymerization of methyl methacrylate. The 5 μm thick coatings deposited on Ti6Al4V have a smooth surface, are homogeneous, transparent, free of pores and cracks, and show a strong adhesion to the metallic substrate (11.6 MPa). Electrochemical impedance spectroscopy results proved an excellent anticorrosive performance of the coating, with an impedance modulus of 26 GΩ cm2 and long-term durability in simulated body fluid (SBF) solution. Moreover, after 21 days of immersion in SBF, the PMMA-silica coating presented apatite crystal deposits, which suggests in vivo bone bioactivity. This was confirmed by biological character- ization showing enhanced osteoblast proliferation, explained by the increased surface free energy and protein adsorption. The obtained results suggest that PMMA-silica hybrids can act in a dual role as efficient anticorrosive and bioactive coating for Ti6Al4V alloys",

keywords = "Organic-inorganic coating, Corrosion protection, Biomaterial, Bioactive coating, Ti6Al4V alloy, PMMA-silica hybrid",

author = "Harb, {Samarah V.} and Uvida, {Mayara C.} and Andressa Trentin and Lobo, {Anderson O.} and Thomas Webster and Pulcinelli, {Sandra H.} and Santilli, {Celso V.} and Peter Hammer",

note = "Funding Information: This work was supported by Coordena{\c c}{\~a}o de Aperfei{\c c}oamento de Pessoal de N{\'i}vel Superior - Brasil (CAPES), Conselho Nacional de Desenvolvimento Cient{\'i}fico e Tecnol{\'o}gico (CNPq) and Funda{\c c}{\~a}o de Amparo {\`a} Pesquisa do Estado de S{\~a}o Paulo (FAPESP). Samarah V. Harb and Andressa Trentin have received scholarships, process No. 2015/09342-7 and 2015/11907-2, respectively, from FAPESP, and Mayara C. Uvida has received a scholarship from INCT Tecnologias Ecoeficientes Avan{\c c}adas em Produtos Ciment{\'i}cios Advanced Eco-efficient Cement-Based Technologies – CEMtec Capes process 88887.136401/2017-00 CAPES - Finance Code 001. Anderson O. Lobo acknowledges the CNPq (# 303752/2017-3 ) for financial support. Publisher Copyright: {\textcopyright} 2020 Elsevier B.V. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

year = "2020",

month = may,

doi = "10.1016/j.msec.2020.110713",

language = "English",

volume = "110",

journal = "Materials Science and Engineering: A",

issn = "0921-5093",

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T1 - PMMA-silica nanocomposite coating: Effective corrosion protection and biocompatibility for a Ti6Al4V alloy

AU - Harb, Samarah V.

AU - Uvida, Mayara C.

AU - Trentin, Andressa

AU - Lobo, Anderson O.

AU - Webster, Thomas

AU - Pulcinelli, Sandra H.

AU - Santilli, Celso V.

AU - Hammer, Peter

N1 - Funding Information: This work was supported by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Samarah V. Harb and Andressa Trentin have received scholarships, process No. 2015/09342-7 and 2015/11907-2, respectively, from FAPESP, and Mayara C. Uvida has received a scholarship from INCT Tecnologias Ecoeficientes Avançadas em Produtos Cimentícios Advanced Eco-efficient Cement-Based Technologies – CEMtec Capes process 88887.136401/2017-00 CAPES - Finance Code 001. Anderson O. Lobo acknowledges the CNPq (# 303752/2017-3 ) for financial support. Publisher Copyright: © 2020 Elsevier B.V. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020/5

Y1 - 2020/5

N2 - Ti6Al4V is the mostly applied metallic alloy for orthopedic and dental implants, however, its lack of osseoin- tegration and poor long-term corrosion resistance often leads to a secondary surgical intervention, recovery delay and toxicity to the surrounding tissue. As a potential solution of these issues poly(methyl methacrylate)- silicon dioxide (PMMA-silica) coatings have been applied on a Ti6Al4V alloy to act simultaneously as an an- ticorrosive barrier and bioactive film. The nanocomposite, composed of PMMA covalently bonded to the silica phase through 3-(trimethoxysilyl)propyl methacrylate (MPTS), has been synthesized combining the sol-gel process with radical polymerization of methyl methacrylate. The 5 μm thick coatings deposited on Ti6Al4V have a smooth surface, are homogeneous, transparent, free of pores and cracks, and show a strong adhesion to the metallic substrate (11.6 MPa). Electrochemical impedance spectroscopy results proved an excellent anticorrosive performance of the coating, with an impedance modulus of 26 GΩ cm2 and long-term durability in simulated body fluid (SBF) solution. Moreover, after 21 days of immersion in SBF, the PMMA-silica coating presented apatite crystal deposits, which suggests in vivo bone bioactivity. This was confirmed by biological character- ization showing enhanced osteoblast proliferation, explained by the increased surface free energy and protein adsorption. The obtained results suggest that PMMA-silica hybrids can act in a dual role as efficient anticorrosive and bioactive coating for Ti6Al4V alloys

AB - Ti6Al4V is the mostly applied metallic alloy for orthopedic and dental implants, however, its lack of osseoin- tegration and poor long-term corrosion resistance often leads to a secondary surgical intervention, recovery delay and toxicity to the surrounding tissue. As a potential solution of these issues poly(methyl methacrylate)- silicon dioxide (PMMA-silica) coatings have been applied on a Ti6Al4V alloy to act simultaneously as an an- ticorrosive barrier and bioactive film. The nanocomposite, composed of PMMA covalently bonded to the silica phase through 3-(trimethoxysilyl)propyl methacrylate (MPTS), has been synthesized combining the sol-gel process with radical polymerization of methyl methacrylate. The 5 μm thick coatings deposited on Ti6Al4V have a smooth surface, are homogeneous, transparent, free of pores and cracks, and show a strong adhesion to the metallic substrate (11.6 MPa). Electrochemical impedance spectroscopy results proved an excellent anticorrosive performance of the coating, with an impedance modulus of 26 GΩ cm2 and long-term durability in simulated body fluid (SBF) solution. Moreover, after 21 days of immersion in SBF, the PMMA-silica coating presented apatite crystal deposits, which suggests in vivo bone bioactivity. This was confirmed by biological character- ization showing enhanced osteoblast proliferation, explained by the increased surface free energy and protein adsorption. The obtained results suggest that PMMA-silica hybrids can act in a dual role as efficient anticorrosive and bioactive coating for Ti6Al4V alloys

KW - Organic-inorganic coating

KW - Corrosion protection

KW - Biomaterial

KW - Bioactive coating

KW - Ti6Al4V alloy

KW - PMMA-silica hybrid

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UR - http://www.scopus.com/inward/record.url?scp=85078936115&partnerID=8YFLogxK

U2 - 10.1016/j.msec.2020.110713

DO - 10.1016/j.msec.2020.110713

M3 - Article

SN - 0921-5093

VL - 110

JO - Materials Science and Engineering: A

JF - Materials Science and Engineering: A

M1 - 110713

ER -

PMMA-silica nanocomposite coating: Effective corrosion protection and biocompatibility for a Ti6Al4V alloy

Abstract

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Keywords

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