Polydopamine-Gelatin as universal cell-interactive coating for methacrylate-based medical device packaging materials: when surface chemistry overrules substrate bulk properties

Elke Van de Walle, Ine Nieuwenhove , Els Vanderleyden , Heidi Declercq , Karolien Gellynck , David Schaubroeck , Heidi Ottevaere, Hugo Thienpont, Winnok H. De Vos, Maria Cornelissen , Sandra Van Vlierberghe, Peter Dubruel

Research output: Contribution to journalArticle

18 Citations (Scopus)
17 Downloads (Pure)

Abstract

Despite its widespread application in the fields of ophthalmology, orthopedics, and dentistry and the stringent need for polymer packagings that induce in vivo tissue integration, the full potential of poly(methyl methacrylate) (PMMA) and its derivatives as medical device packaging material has not been explored yet. We therefore elaborated on the development of a universal coating for methacrylate-based materials that ideally should reveal cell-interactivity irrespective of the polymer substrate bulk properties. Within this perspective, the present work reports on the UV-induced synthesis of PMMA and its more flexible poly(ethylene glycol) (PEG)-based derivative (PMMAPEG) and its subsequent surface decoration using polydopamine (PDA) as well as PDA combined with gelatin B (Gel B). Successful application of both layers was confirmed by multiple surface characterization techniques. The cell interactivity of the materials was studied by performing live-dead assays and immunostainings of the cytoskeletal components of fibroblasts. It can be concluded that only the combination of PDA and Gel B yields materials possessing similar cell interactivities, irrespective of the physicochemical properties of the underlying substrate. The proposed coating outperforms both the PDA functionalized and the pristine polymer surfaces. A universal cell-interactive coating for methacrylate-based medical device packaging materials has thus been realized.
Original languageEnglish
Pages (from-to)56-68
Number of pages12
JournalBiomacromolecules
Volume17
Issue number1
DOIs
Publication statusPublished - Jan 2016

Keywords

  • POLY(METHYL METHACRYLATE);
  • MECHANICAL-PROPERTIES
  • BONE CEMENTS;
  • BIOMEDICAL APPLICATIONS
  • ORTHOPEDIC APPLICATIONS
  • POLYETHYLENE-GLYCOLS;
  • PLASMA TREATMENT
  • SERUM-ALBUMIN
  • ADHESION;
  • GROWTH

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