Pore

Han Remaut (Inventor), Sander Van Der Verren (Inventor), Nani Van Gerven (Inventor), Lakmal Nishanta Jayasinghe (Inventor), Elizabeth Jayne Wallace (Inventor), Pratik Raj Singh (Inventor), Richard George Hambley (Inventor), Michael Robert Jordan (Inventor), John Joseph Kilgour (Inventor), Andre Heron (Inventor)

Research output: Patent

Abstract

A system for characterising a target polynucleotide, the system comprising a membrane and a pore complex; wherein the pore complex comprises: (i) a nanopore located in the membrane, and (ii) an auxiliary protein or peptide attached to the nanopore; wherein the nanopore and the auxiliary protein or peptide together form a continuous channel across the membrane, the channel comprising a first constriction region and a second constriction region; wherein the first constriction region is formed by a portion of the nanopore, and wherein the second constriction region is formed by at least a portion of the auxiliary protein or peptide.
Original languageEnglish
Patent numberWO2020095052
Publication statusPublished - 2020

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