Poster: Connexin43 hemichannel inhibition exerts anticonvulsant effects against experimentally induced limbic seizures

Laura Walrave; Mathieu Vinken; Luc Leybaert; Ilse Julia Smolders

Poster: Connexin43 hemichannel inhibition exerts anticonvulsant effects against experimentally induced limbic seizures

Laura Walrave, Mathieu Vinken, Luc Leybaert, Ilse Julia Smolders

Research output: Chapter in Book/Report/Conference proceeding › Meeting abstract (Book)

Abstract

Pharmacoresistance remains a major problem for 30-40 % of patients with temporal lobe epilepsy. Furthermore, the marketed drugs are not completely without side effects. Therefore, the search for new therapies with a safer therapeutic index and better efficacy is clearly warranted. In the current study, we want to screen connexin43 hemichannels (Cx43-HCs) as novel antiepileptic drug targets through the application of TAT-Gap19, a newly developed and selective Cx43-HC inhibitor.

Original language	English
Title of host publication	PhD day Center for Neurosciences (C4N)
Publication status	Published - May 2015
Event	Phd day center for neurosciences - Jette, Belgium Duration: 27 May 2015 → 27 May 2015

Conference

Conference	Phd day center for neurosciences
Country/Territory	Belgium
City	Jette
Period	27/05/15 → 27/05/15

Cite this

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title = "Poster: Connexin43 hemichannel inhibition exerts anticonvulsant effects against experimentally induced limbic seizures",

abstract = "Pharmacoresistance remains a major problem for 30-40 % of patients with temporal lobe epilepsy. Furthermore, the marketed drugs are not completely without side effects. Therefore, the search for new therapies with a safer therapeutic index and better efficacy is clearly warranted. In the current study, we want to screen connexin43 hemichannels (Cx43-HCs) as novel antiepileptic drug targets through the application of TAT-Gap19, a newly developed and selective Cx43-HC inhibitor.",

author = "Laura Walrave and Mathieu Vinken and Luc Leybaert and Smolders, {Ilse Julia}",

year = "2015",

month = may,

language = "English",

booktitle = "PhD day Center for Neurosciences (C4N)",

note = "Phd day center for neurosciences ; Conference date: 27-05-2015 Through 27-05-2015",

}

TY - CHAP

T1 - Poster: Connexin43 hemichannel inhibition exerts anticonvulsant effects against experimentally induced limbic seizures

AU - Walrave, Laura

AU - Vinken, Mathieu

AU - Leybaert, Luc

AU - Smolders, Ilse Julia

PY - 2015/5

Y1 - 2015/5

N2 - Pharmacoresistance remains a major problem for 30-40 % of patients with temporal lobe epilepsy. Furthermore, the marketed drugs are not completely without side effects. Therefore, the search for new therapies with a safer therapeutic index and better efficacy is clearly warranted. In the current study, we want to screen connexin43 hemichannels (Cx43-HCs) as novel antiepileptic drug targets through the application of TAT-Gap19, a newly developed and selective Cx43-HC inhibitor.

AB - Pharmacoresistance remains a major problem for 30-40 % of patients with temporal lobe epilepsy. Furthermore, the marketed drugs are not completely without side effects. Therefore, the search for new therapies with a safer therapeutic index and better efficacy is clearly warranted. In the current study, we want to screen connexin43 hemichannels (Cx43-HCs) as novel antiepileptic drug targets through the application of TAT-Gap19, a newly developed and selective Cx43-HC inhibitor.

M3 - Meeting abstract (Book)

BT - PhD day Center for Neurosciences (C4N)

T2 - Phd day center for neurosciences

Y2 - 27 May 2015 through 27 May 2015

ER -

Poster: Connexin43 hemichannel inhibition exerts anticonvulsant effects against experimentally induced limbic seizures

Abstract

Conference

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