POSTER: System xc as the link between inflammation and neurodegeneration in Parkinson's disease

Research output: Unpublished contribution to conferencePoster

Abstract

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc) and the consequent depletion of striatal dopamine, resulting in both motor and non-motor impairment. Till now, PD can only be treated symptomatically. Failure to translate neuroprotective strategies from pre-clinical to clinical studies might result from the use of animal models in which cell death is caused by limited mechanisms of action. We aim at confirming the involvement of system xc- or the cystine/glutamate antiporter in PD pathology by using a dual-hit model combining peripheral inflammation and toxin-induced models i.e. proteasome inhibition.
Original languageEnglish
Publication statusPublished - 2015
EventCenter for Neurosciences, PhD day - Brussels, Belgium
Duration: 27 Feb 2015 → …

Seminar

SeminarCenter for Neurosciences, PhD day
CountryBelgium
CityBrussels
Period27/02/15 → …

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