Preliminary results on cognitive and motor development of 2-year-old IVM children: Is there a difference in cognitive and motor development between children born after in vitro maturation (IVM), Intra cystoplasmatic injection (ICSI) and spontaneous conceived (SC) pregnancy?

Eveline Buyse, Mélissa Pilloy, Mary-Louise Bonduelle, Julie Nekkebroeck

Research output: Unpublished contribution to conferencePoster

Abstract

Poster P-783 Study question: Is there a difference in cognitive and motor development between children born after In vitro maturation (IVM), Intra cytoplasmatic sperm injection (ICSI) and spontaneous conceived (SC) pregnancy? Summary answer: First results show a significant difference between IVM and SC controls for cognitive development (IVM< SC) and between IVM and ICSI for motor development (IVM<ICSI). What is known already: Several ART follow-up studies show no significant difference in cognitive and motor development between children born after IVF and ICSI compared with SC controls. Studies that looked at children born after IVM treatment focused on medical factors. There are no more significant premature births or major birth problems after IVM compared with other modes of conception (IVF, ICSI, SC) (Buckett et al., 2007, Cha et al., 2005, Shu-Chi et al., 2006, Söderström-Antilla et al., 2006) Data of birth length- and weight of IVM-children compared with other modes of conception are inconclusive. Study design, size, duration: A case-control study design were three groups (IVM, ICSI and SC children) were matched according to age, sex, language, tongue. Recruitment ran from 2014 until 2016. Sixty-nine were invited, 53 participated. Participants/materials, setting, methods: Seventeen IVM, 18 ICSI were invited to the UZ Brussel. Eighteen SC children were recruited in a nursery. The IVM mean age of assessment was 25 months (SD=3.47), for ICSI and SC 27 months (SD=4.22/ SD=4.63). Cognitive and motor development was investigated using the Bayley Scales of Infant Development II, Dutch version. The scales were administered yielding a mental index score and motor index score with a mean of 100 and a SD of 15. Main results and the role of chance: The results on the B S I D- II-NL show significant differences between the three groups for cognitive and motor development. There is a significant difference on the mental index score between the IVM and de SC control group (F= 4.68, p= .014). The SC controls (M= 108.78, SD= 4.41) score higher than the IVM group (M= 101.47, SD= 9.37). There is also a significant difference on the motor index score between the IVM and the ICSI group (F= 4.26, p= .019). The ICSI group (M= 111.50, SD= 8.34) score higher than the IVM group (M= 103.89, SD= 9.92). None of the children show a delayed cognitive and motor development. Limitations, reasons for caution: This study used multiple evaluators, giving a potential evaluators bias. Although significant differences were found, scores in all three conception groups are within a normal range. The small sample size undermines the generalizability of the results to the population. The results presented in this abstract are of a preliminary nature. Wider implications of the findings: The IVM and ICSI treatment does not have a negative impact on the cognitive and motor development of children compared with SC controls. The small sample size and limited IVM studies require further investigation. Trial registration number: Non-randomised study design. ethnicity, mothers educational level, maternal age and birth order. All children are singletons, live in Belgium and have Dutch or French as mother
Original languageEnglish
Pagesi495
Number of pages1
Publication statusPublished - 1 Jul 2017
Event33rd Annual Meeting of ESHRE - Geneva, Switzerland
Duration: 2 Jul 20175 Jul 2017

Conference

Conference33rd Annual Meeting of ESHRE
CountrySwitzerland
CityGeneva
Period2/07/175/07/17

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