TY - JOUR
T1 - Preparation and Characterization of Mono- and Biphasic Ca1-xAgxHPO4·nH2O Compounds for Biomedical Applications
AU - Abdulaziz, Fahad
AU - Issa, Khalil
AU - Alyami, Mohammed
AU - Alotibi, Satam
AU - Alanazi, Abdulaziz A
AU - Taha, Taha Abdel Mohaymen
AU - Saad, Asma M E
AU - Hammouda, Gehan A
AU - Hamad, Nagat
AU - Alshaaer, Mazen
N1 - Funding Information:
This study was supported by funding from Prince Sattam bin Abdulaziz University (project number PSAU/2023/R/1444).
Publisher Copyright:
© 2023 by the authors.
PY - 2023/11/14
Y1 - 2023/11/14
N2 - This study aimed to explore the effects of the full-scale replacement (up to 100%) of Ca2+ ions with Ag1+ ions in the structure of brushite (CaHPO4·2H2O). This substitution has potential benefits for producing monophasic and biphasic Ca1-xAgxHPO4·nH2O compounds. To prepare the starting solutions, (NH4)2HPO4, Ca(NO3)2·4H2O, and AgNO3 at different concentrations were used. The results showed that when the Ag/Ca molar ratio was below 0.25, partial substitution of Ca with Ag reduced the size of the unit cell of brushite. As the Ag/Ca molar ratio increased to 4, a compound with both monoclinic CaHPO4·2H2O and cubic nanostructured Ag3PO4 phases formed. There was a nearly linear relationship between the Ag ion ratio in the starting solutions and the wt% precipitation of the Ag3PO4 phase in the resulting compound. Moreover, when the Ag/Ca molar ratio exceeded 4, a single-phase Ag3PO4 compound formed. Hence, adjusting the Ag/Ca ratio in the starting solution allows the production of biomaterials with customized properties. In summary, this study introduces a novel synthesis method for the mono- and biphasic Ca1-xAgxHPO4·nH2O compounds brushite and silver phosphate. The preparation of these phases in a one-pot synthesis with controlled phase composition resulted in the enhancement of existing bone cement formulations by allowing better mixing of the starting ingredients.
AB - This study aimed to explore the effects of the full-scale replacement (up to 100%) of Ca2+ ions with Ag1+ ions in the structure of brushite (CaHPO4·2H2O). This substitution has potential benefits for producing monophasic and biphasic Ca1-xAgxHPO4·nH2O compounds. To prepare the starting solutions, (NH4)2HPO4, Ca(NO3)2·4H2O, and AgNO3 at different concentrations were used. The results showed that when the Ag/Ca molar ratio was below 0.25, partial substitution of Ca with Ag reduced the size of the unit cell of brushite. As the Ag/Ca molar ratio increased to 4, a compound with both monoclinic CaHPO4·2H2O and cubic nanostructured Ag3PO4 phases formed. There was a nearly linear relationship between the Ag ion ratio in the starting solutions and the wt% precipitation of the Ag3PO4 phase in the resulting compound. Moreover, when the Ag/Ca molar ratio exceeded 4, a single-phase Ag3PO4 compound formed. Hence, adjusting the Ag/Ca ratio in the starting solution allows the production of biomaterials with customized properties. In summary, this study introduces a novel synthesis method for the mono- and biphasic Ca1-xAgxHPO4·nH2O compounds brushite and silver phosphate. The preparation of these phases in a one-pot synthesis with controlled phase composition resulted in the enhancement of existing bone cement formulations by allowing better mixing of the starting ingredients.
UR - http://www.scopus.com/inward/record.url?scp=85178115638&partnerID=8YFLogxK
U2 - 10.3390/biomimetics8070547
DO - 10.3390/biomimetics8070547
M3 - Article
C2 - 37999188
SN - 2313-7673
VL - 8
JO - Biomimetics (Basel, Switzerland)
JF - Biomimetics (Basel, Switzerland)
IS - 7
M1 - 547
ER -