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Abstract
BACKGROUND: The phenotypic heterogeneity of Brugada syndrome (BrS) can lead some patients to show an additional inferolateral early repolarization pattern (ERP), or fragmented QRS (f-QRS). The aim of the study was to investigate the prevalence and clinical impact of f-QRS, ERP or combined f-QRS/ERP in high-risk patients with BrS.Methods and Results:Patients with spontaneous or drug-induced BrS and an indication to receive an implantable cardioverter-defibrillator (ICD) were considered eligible for this study. From 1992 to 2012, a total of 176 consecutive patients with BrS underwent ICD implantation. Among them, 48 subjects (27.3%) presented with additional depolarization and/or repolarization abnormalities. f-QRS was found in 29 (16.5%), ERP in 15 (8.5%), and combined f-QRS/ERP in 4 patients (2.3%). After a mean follow-up of 95.2±51.9 months, spontaneous sustained ventricular arrhythmias were documented in 8 patients (16.7%). No significant difference was found in the rate of appropriate shocks between patients presenting with f-QRS or ERP and those without abnormalities. Patients with both f-QRS and ERP had a significantly higher rate of appropriate shocks (HR: 4.1; 95% CI: 1.1-19.7; P=0.04).
CONCLUSIONS: Fragmented QRS and ERP are common ECG findings in high-risk BrS patients, occurring in up to 27% of cases. When combined, f-QRS and ERP confer a higher risk of appropriate ICD interventions during a very long-term follow-up.
Original language | English |
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Pages (from-to) | 2109-2116 |
Number of pages | 8 |
Journal | Circulation Journal |
Volume | 80 |
Issue number | 10 |
DOIs | |
Publication status | Published - 23 Sep 2016 |
Keywords
- Cryoballoon
- Pulmonary vein isolation
- Repeat procedures
- Brugada syndrome
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Dive into the research topics of 'Prevalence and Clinical Impact of Early Repolarization Pattern and QRS-Fragmentation in High-Risk Patients With Brugada Syndrome'. Together they form a unique fingerprint.Projects
- 1 Finished
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IRP8_a: IMAGica: an Integrative personalised Medical Approach for Genetic diseases, Inherited Cardiac Arrhythmias as a model
Nowe, A., Bonduelle, M., Brugada, P., Deschepper, R., Lenaerts, T., Van Dooren, S., De Asmundis, C., Gidron, Y., Bilsen, J. & De Couck, M.
1/07/16 → 30/06/23
Project: Fundamental