Prevalence and impact on FEV1 decline of methicillin-resistant Staphylococcus aureus infection in patients with cystic fibrosis

Research output: Contribution to journalMeeting abstract (Journal)

Abstract

Rationale: Risk factors for methicillin-resistant Staphylococcus aureus (MRSA) in Cystic Fibrosis (CF) and the impact on CF disease progression are still under debate.

Objectives: To study clinical variables associated with MRSA infection and examine impact on FEV1 evolution in CF patients.

Methods: A retrospective case-control study from 2002 to 2010, comparing clinical variables and decline of FEV1 of MRSA positive patients with age-and sex matched controls.

Results: Thirty of the 165 CF patients (18.2%) had cultures positive for MRSA. Excluding patients under 4 years, the prevalence became 15.2% (23/151). Chronic infection was found in 19/151 (12.6%).

Most apparent differences between the groups were: a higher proportion of patients with genotype F508del, less pancreas sufficient patients, more bronchiectasis and more frequent hospitalization in the MRSA group.

The FEV1 recorded one year prior to, and at the moment of MRSA infection, was not significantly different from that obtained in controls. However, FEV1 decline over 2 and 6 year periods, were significantly greater in the MRSA group than in the controls. In fact, over a 6 year period FEV1 decline amounted to -2.6% versus -1.3%predicted per year in the MRSA group and controls respectively (p=0.031).

Conclusion: Prevalence of MRSA in CF patients averaged 15%, and MRSA infection was shown to be associated with a particular genotype, presence of bronchiectasis and hospitalization. Our spirometric data also clearly show that a MRSA episode entails an FEV1 decline that is almost double that predicted for CF patients who can remain unaffected by MRSA.
Original languageEnglish
Pages (from-to)4565-4565
Number of pages1
JournalEur Respir J
Volume38
Issue numbers55
Publication statusPublished - 2011

Keywords

  • cystic fibrosis

Fingerprint

Dive into the research topics of 'Prevalence and impact on FEV1 decline of methicillin-resistant Staphylococcus aureus infection in patients with cystic fibrosis'. Together they form a unique fingerprint.

Cite this