TY - JOUR
T1 - Prevalence of mechanical dyssynchrony in patients with heart failure and preserved left ventricular function (a report from the Belgian Multicenter registry on dyssynchrony).
AU - De Sutter, Johan
AU - Van De Veire, Nico
AU - Muyldermans, L.
AU - Debacker, Tibaut
AU - Hoffer, E.
AU - Vaerenberg, M.
AU - Paelinck, B.
AU - Decoodt, P.
AU - Gabriel, L.
AU - Gillebert, T.
AU - Van Camp, Guy
PY - 2005/12/1
Y1 - 2005/12/1
N2 - Abstract: The present study evaluated the prevalence of mechanical inter- and intraventricular dyssynchrony in patients with heart failure and preserved left ventricular (LV) ejection fraction (LVEF). We studied 138 patients with heart failure (age 67 +/- 11 years; 76% men); 60 patients had preserved LVEF (> 40%). Using conventional Doppler echocardiography, an interventricular mechanical delay >= 40 ms was defined as interventricular dyssynchrony. Using pulse-wave tissue Doppler imaging, the time from the beginning of the QRS complex to onset of systolic motion was measured in 4 basal LV segments. A dispersion of >= 60 ms was defined as intraventricular dyssynchrony. The prevalence of inter- and intraventricular dyssynchrony was lower in patients with preserved LVEF than in those with reduced LVEF (17% vs 41%, p <0.01 for interventricular dyssynchrony, 18% vs 36%, p <0.01 for intraventricular dyssynchrony). However, patients with preserved LVEF and a QRS width >= 120 ms had higher values for the parameters for inter- and intraventricular dyssynchrony than patients with a QRS width <120 ms (interventricular mechanical delay 33 +/- 20 vs 20 +/- 16 ms, p <0.05; tissue Doppler imaging dispersion 42 +/- 26 vs 33 22 ms, p <0.05). In patients with a QRS width >= 120 ms, the prevalence of inter- and intraventricular dyssynchrony was comparable for patients with preserved and reduced LVEF (42% vs 55%, p = NS for interventricular dyssynchrony and 45% vs 46%, p = NS for intraventricular dyssynchrony). In conclusion, the prevalence of inter- and intraventricular dyssynchrony was low (17% and 18%, respectively) in patients with heart failure and preserved LVEF. However, in the presence of a QRS width of >= 120 ms, this prevalence increased to almost 50%, comparable to that for patients with heart failure and reduced LVEF and a QRS width of >= 120 ms. (c) 2005 Elsevier Inc. All rights reserved.
AB - Abstract: The present study evaluated the prevalence of mechanical inter- and intraventricular dyssynchrony in patients with heart failure and preserved left ventricular (LV) ejection fraction (LVEF). We studied 138 patients with heart failure (age 67 +/- 11 years; 76% men); 60 patients had preserved LVEF (> 40%). Using conventional Doppler echocardiography, an interventricular mechanical delay >= 40 ms was defined as interventricular dyssynchrony. Using pulse-wave tissue Doppler imaging, the time from the beginning of the QRS complex to onset of systolic motion was measured in 4 basal LV segments. A dispersion of >= 60 ms was defined as intraventricular dyssynchrony. The prevalence of inter- and intraventricular dyssynchrony was lower in patients with preserved LVEF than in those with reduced LVEF (17% vs 41%, p <0.01 for interventricular dyssynchrony, 18% vs 36%, p <0.01 for intraventricular dyssynchrony). However, patients with preserved LVEF and a QRS width >= 120 ms had higher values for the parameters for inter- and intraventricular dyssynchrony than patients with a QRS width <120 ms (interventricular mechanical delay 33 +/- 20 vs 20 +/- 16 ms, p <0.05; tissue Doppler imaging dispersion 42 +/- 26 vs 33 22 ms, p <0.05). In patients with a QRS width >= 120 ms, the prevalence of inter- and intraventricular dyssynchrony was comparable for patients with preserved and reduced LVEF (42% vs 55%, p = NS for interventricular dyssynchrony and 45% vs 46%, p = NS for intraventricular dyssynchrony). In conclusion, the prevalence of inter- and intraventricular dyssynchrony was low (17% and 18%, respectively) in patients with heart failure and preserved LVEF. However, in the presence of a QRS width of >= 120 ms, this prevalence increased to almost 50%, comparable to that for patients with heart failure and reduced LVEF and a QRS width of >= 120 ms. (c) 2005 Elsevier Inc. All rights reserved.
KW - CARDIAC RESYNCHRONIZATION THERAPY
KW - ECHOCARDIOGRAPHIC EVALUATION
KW - INTRAVENTRICULAR DYSSYNCHRONY
KW - EJECTION FRACTION
KW - CONDUCTION DELAY
KW - ASYNCHRONY
M3 - Article
SN - 0002-9149
VL - 96
SP - 1543
EP - 1548
JO - The American Journal of Cardiology
JF - The American Journal of Cardiology
IS - 11
ER -