Abstract

Liver disorders constitute a worldwide increasing problem. Both the study of the mechanisms underlying liver disease and the development of liver disease therapeutics heavily rely on the use of experimental models. Among those, human-based in vitro systems are more and more preferred over laboratory animals because of ethical reasons. Primary human hepatocytes and their cultures are still considered as the gold standard liver-based in vitro models, as they provide a good reflection of the in vivo situation. Nevertheless, these in vitro systems deal with the gradual deterioration of the differentiated morphological and functional phenotype. This can be overcome by following a number of strategies, such as by using spheroid/organoid and sandwich culture configurations. Further improvement in this area in view of enhancing overall translational value of primary human hepatocytes and their cultures warrants interdisciplinary collaboration.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalCurrent Opinion in Toxicology
Volume25
DOIs
Publication statusPublished - 1 Mar 2021

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