Prognostic Value of Programmed Electrical Stimulation in Brugada Syndrome: 20 Years Experience

Juan  Sieira; Giulio Conte; Giuseppe Ciconte; Carlo De Asmundis; Gian-Battista Chierchia; Giannis Baltogiannis; Giacomo Di Giovanni; Yukio Saitoh; Ghazala Irfan; Ruben Casado-Arroyo; Justo Juliá; Mark La Meir; Francis Wellens; Kristel Wauters; Sophie Van Malderen; Gudrun Pappaert; Pedro Brugada

doi:10.1161/CIRCEP.114.002647

Prognostic Value of Programmed Electrical Stimulation in Brugada Syndrome: 20 Years Experience

Juan Sieira, Giulio Conte, Giuseppe Ciconte, Carlo De Asmundis, Gian-Battista Chierchia, Giannis Baltogiannis, Giacomo Di Giovanni, Yukio Saitoh, Ghazala Irfan, Ruben Casado-Arroyo, Justo Juliá, Mark La Meir, Francis Wellens, Kristel Wauters, Sophie Van Malderen, Gudrun Pappaert, Pedro Brugada

Research output: Contribution to journal › Article › peer-review

96 Citations (Scopus)

Abstract

BACKGROUND: -The prognostic value of electrophysiological investigations in individuals with Brugada syndrome remains controversial. Different groups have published contradictory data. Long-term follow up is needed to clarify this issue.

METHODS AND RESULTS: -Patients presenting with spontaneous or drug-induced Brugada type I electrocardiogram (ECG) and in whom PES was performed at our institution were considered eligible for this study. A total of 403 consecutive patients (235 males, 58.2%; mean age: 43.2±16.2 years) were included. VA during PES were induced in 73 (18.1%) patients. After a mean follow-up time of 74.3±57.3 months, (median 57.3), 25 arrhythmic events occurred (16 in the inducible group and 9 in the non inducible). VA inducibility presented a hazard ratio for events of 8.3 (95% CI 3.6 - 19.4), p<0.01.

CONCLUSIONS: -Programmed ventricular stimulation of the heart is a good predictor of outcome in individuals with Brugada syndrome. It might be of special value to guide further management when performed in asymptomatic individuals. The over- all accuracy of the test makes it a suitable screening tool to reassure non-inducible asymptomatic individuals.

Original language	English
Pages (from-to)	777-784
Number of pages <span style="color:red"p> <font size="1.5"> ✽ </span> </font>	8
Journal	Circulation: Arrhythmia and Electrophysiology
Volume	8
Issue number	4
Early online date	22 Apr 2015
DOIs	https://doi.org/10.1161/CIRCEP.114.002647 https://doi.org/10.1161/CIRCEP.114.002647
Publication status	Published - 22 Aug 2015

Keywords

arrhythmias
Brugada syndrome
cardiac
electrophysiology
prognosis
implantable cardioverter defibrillator
ajmaline
flecainide
procainamide
acute heart infarction
adolescent
adult
aged
article
atrial fibrillation
cardiogenic shock
cause of death
child
device infection
ECG abnormality
electrocardiogram
electrostimulation
event free survival
faintness
female
follow up
heart electrophysiology
heart rupture
heart stimulation
heart supraventricular arrhythmia
heart ventricle arrhythmia
heart ventricle extrasystole
human
lead dislocation
lead fracture
major clinical study
male
medical device complication
pacemaker implantation
predictive value
priority journal
programmed electrical stimulation
prospective study
pulse generator migration
QT prolongation
second degree atrioventricular block
septic shock
sinus node disease
sinus tachycardia
ST segment elevation
T wave
very elderly

Access to Document

Cite this

Sieira, J., Conte, G., Ciconte, G., De Asmundis, C., Chierchia, G-B., Baltogiannis, G., Di Giovanni, G., Saitoh, Y., Irfan, G., Casado-Arroyo, R., Juliá, J., La Meir, M., Wellens, F., Wauters, K., Van Malderen, S., Pappaert, G., & Brugada, P. (2015). Prognostic Value of Programmed Electrical Stimulation in Brugada Syndrome: 20 Years Experience. Circulation: Arrhythmia and Electrophysiology, 8(4), 777-784. https://doi.org/10.1161/CIRCEP.114.002647, https://doi.org/10.1161/CIRCEP.114.002647

Sieira, Juan ; Conte, Giulio ; Ciconte, Giuseppe ; De Asmundis, Carlo ; Chierchia, Gian-Battista ; Baltogiannis, Giannis ; Di Giovanni, Giacomo ; Saitoh, Yukio ; Irfan, Ghazala ; Casado-Arroyo, Ruben ; Juliá, Justo ; La Meir, Mark ; Wellens, Francis ; Wauters, Kristel ; Van Malderen, Sophie ; Pappaert, Gudrun ; Brugada, Pedro. / Prognostic Value of Programmed Electrical Stimulation in Brugada Syndrome : 20 Years Experience. In: Circulation: Arrhythmia and Electrophysiology. 2015 ; Vol. 8, No. 4. pp. 777-784.

@article{bbde6e99f0634caab60fd1c0b732ee75,

title = "Prognostic Value of Programmed Electrical Stimulation in Brugada Syndrome: 20 Years Experience",

abstract = "BACKGROUND: -The prognostic value of electrophysiological investigations in individuals with Brugada syndrome remains controversial. Different groups have published contradictory data. Long-term follow up is needed to clarify this issue.METHODS AND RESULTS: -Patients presenting with spontaneous or drug-induced Brugada type I electrocardiogram (ECG) and in whom PES was performed at our institution were considered eligible for this study. A total of 403 consecutive patients (235 males, 58.2%; mean age: 43.2±16.2 years) were included. VA during PES were induced in 73 (18.1%) patients. After a mean follow-up time of 74.3±57.3 months, (median 57.3), 25 arrhythmic events occurred (16 in the inducible group and 9 in the non inducible). VA inducibility presented a hazard ratio for events of 8.3 (95% CI 3.6 - 19.4), p<0.01.CONCLUSIONS: -Programmed ventricular stimulation of the heart is a good predictor of outcome in individuals with Brugada syndrome. It might be of special value to guide further management when performed in asymptomatic individuals. The over- all accuracy of the test makes it a suitable screening tool to reassure non-inducible asymptomatic individuals.",

keywords = "arrhythmias, Brugada syndrome, cardiac, electrophysiology, prognosis, implantable cardioverter defibrillator, ajmaline, flecainide, procainamide, acute heart infarction, adolescent, adult, aged, article, atrial fibrillation, cardiogenic shock, cause of death, child, device infection, ECG abnormality, electrocardiogram, electrostimulation, event free survival, faintness, female, follow up, heart electrophysiology, heart rupture, heart stimulation, heart supraventricular arrhythmia, heart ventricle arrhythmia, heart ventricle extrasystole, human, lead dislocation, lead fracture, major clinical study, male, medical device complication, pacemaker implantation, predictive value, priority journal, programmed electrical stimulation, prospective study, pulse generator migration, QT prolongation, second degree atrioventricular block, septic shock, sinus node disease, sinus tachycardia, ST segment elevation, T wave, very elderly",

author = "Juan Sieira and Giulio Conte and Giuseppe Ciconte and {De Asmundis}, Carlo and Gian-Battista Chierchia and Giannis Baltogiannis and {Di Giovanni}, Giacomo and Yukio Saitoh and Ghazala Irfan and Ruben Casado-Arroyo and Justo Juli{\'a} and {La Meir}, Mark and Francis Wellens and Kristel Wauters and {Van Malderen}, Sophie and Gudrun Pappaert and Pedro Brugada",

year = "2015",

month = aug,

day = "22",

doi = "10.1161/CIRCEP.114.002647",

language = "English",

volume = "8",

pages = "777--784",

journal = "Circulation: Arrhythmia and Electrophysiology",

issn = "1941-3149",

publisher = "Lippincott Williams and Wilkins",

number = "4",

}

Sieira, J, Conte, G, Ciconte, G, De Asmundis, C , Chierchia, G-B, Baltogiannis, G, Di Giovanni, G, Saitoh, Y, Irfan, G, Casado-Arroyo, R, Juliá, J, La Meir, M , Wellens, F , Wauters, K, Van Malderen, S, Pappaert, G & Brugada, P 2015, 'Prognostic Value of Programmed Electrical Stimulation in Brugada Syndrome: 20 Years Experience', Circulation: Arrhythmia and Electrophysiology, vol. 8, no. 4, pp. 777-784. https://doi.org/10.1161/CIRCEP.114.002647, https://doi.org/10.1161/CIRCEP.114.002647

Prognostic Value of Programmed Electrical Stimulation in Brugada Syndrome : 20 Years Experience. / Sieira, Juan ; Conte, Giulio; Ciconte, Giuseppe; De Asmundis, Carlo ; Chierchia, Gian-Battista; Baltogiannis, Giannis; Di Giovanni, Giacomo; Saitoh, Yukio; Irfan, Ghazala; Casado-Arroyo, Ruben; Juliá, Justo; La Meir, Mark ; Wellens, Francis ; Wauters, Kristel; Van Malderen, Sophie; Pappaert, Gudrun ; Brugada, Pedro.

In: Circulation: Arrhythmia and Electrophysiology, Vol. 8, No. 4, 22.08.2015, p. 777-784.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Prognostic Value of Programmed Electrical Stimulation in Brugada Syndrome

T2 - 20 Years Experience

AU - Sieira, Juan

AU - Conte, Giulio

AU - Ciconte, Giuseppe

AU - De Asmundis, Carlo

AU - Chierchia, Gian-Battista

AU - Baltogiannis, Giannis

AU - Di Giovanni, Giacomo

AU - Saitoh, Yukio

AU - Irfan, Ghazala

AU - Casado-Arroyo, Ruben

AU - Juliá, Justo

AU - La Meir, Mark

AU - Wellens, Francis

AU - Wauters, Kristel

AU - Van Malderen, Sophie

AU - Pappaert, Gudrun

AU - Brugada, Pedro

PY - 2015/8/22

Y1 - 2015/8/22

N2 - BACKGROUND: -The prognostic value of electrophysiological investigations in individuals with Brugada syndrome remains controversial. Different groups have published contradictory data. Long-term follow up is needed to clarify this issue.METHODS AND RESULTS: -Patients presenting with spontaneous or drug-induced Brugada type I electrocardiogram (ECG) and in whom PES was performed at our institution were considered eligible for this study. A total of 403 consecutive patients (235 males, 58.2%; mean age: 43.2±16.2 years) were included. VA during PES were induced in 73 (18.1%) patients. After a mean follow-up time of 74.3±57.3 months, (median 57.3), 25 arrhythmic events occurred (16 in the inducible group and 9 in the non inducible). VA inducibility presented a hazard ratio for events of 8.3 (95% CI 3.6 - 19.4), p<0.01.CONCLUSIONS: -Programmed ventricular stimulation of the heart is a good predictor of outcome in individuals with Brugada syndrome. It might be of special value to guide further management when performed in asymptomatic individuals. The over- all accuracy of the test makes it a suitable screening tool to reassure non-inducible asymptomatic individuals.

AB - BACKGROUND: -The prognostic value of electrophysiological investigations in individuals with Brugada syndrome remains controversial. Different groups have published contradictory data. Long-term follow up is needed to clarify this issue.METHODS AND RESULTS: -Patients presenting with spontaneous or drug-induced Brugada type I electrocardiogram (ECG) and in whom PES was performed at our institution were considered eligible for this study. A total of 403 consecutive patients (235 males, 58.2%; mean age: 43.2±16.2 years) were included. VA during PES were induced in 73 (18.1%) patients. After a mean follow-up time of 74.3±57.3 months, (median 57.3), 25 arrhythmic events occurred (16 in the inducible group and 9 in the non inducible). VA inducibility presented a hazard ratio for events of 8.3 (95% CI 3.6 - 19.4), p<0.01.CONCLUSIONS: -Programmed ventricular stimulation of the heart is a good predictor of outcome in individuals with Brugada syndrome. It might be of special value to guide further management when performed in asymptomatic individuals. The over- all accuracy of the test makes it a suitable screening tool to reassure non-inducible asymptomatic individuals.

KW - arrhythmias

KW - Brugada syndrome

KW - cardiac

KW - electrophysiology

KW - prognosis

KW - implantable cardioverter defibrillator

KW - ajmaline

KW - flecainide

KW - procainamide

KW - acute heart infarction

KW - adolescent

KW - adult

KW - aged

KW - article

KW - atrial fibrillation

KW - cardiogenic shock

KW - cause of death

KW - child

KW - device infection

KW - ECG abnormality

KW - electrocardiogram

KW - electrostimulation

KW - event free survival

KW - faintness

KW - female

KW - follow up

KW - heart electrophysiology

KW - heart rupture

KW - heart stimulation

KW - heart supraventricular arrhythmia

KW - heart ventricle arrhythmia

KW - heart ventricle extrasystole

KW - human

KW - lead dislocation

KW - lead fracture

KW - major clinical study

KW - male

KW - medical device complication

KW - pacemaker implantation

KW - predictive value

KW - priority journal

KW - programmed electrical stimulation

KW - prospective study

KW - pulse generator migration

KW - QT prolongation

KW - second degree atrioventricular block

KW - septic shock

KW - sinus node disease

KW - sinus tachycardia

KW - ST segment elevation

KW - T wave

KW - very elderly

U2 - 10.1161/CIRCEP.114.002647

DO - 10.1161/CIRCEP.114.002647

M3 - Article

C2 - 25904495

VL - 8

SP - 777

EP - 784

JO - Circulation: Arrhythmia and Electrophysiology

JF - Circulation: Arrhythmia and Electrophysiology

SN - 1941-3149

IS - 4

ER -

Prognostic Value of Programmed Electrical Stimulation in Brugada Syndrome: 20 Years Experience

Abstract

Keywords

Access to Document

Fingerprint

Cite this