Promising immunomodulatory effects of selected strains of dairy propionibacteria as evidenced in vitro and in vivo

Benoît Foligné, Stéphanie-Marie Deutsch, Jérôme Breton, Fabien J Cousin, Joëlle Dewulf, Michel Samson, Bruno Pot, Gwénaël Jan

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Immunomodulatory properties of 10 dairy propionibacteria, analyzed on human peripheral blood mononuclear cells (PBMCs), revealed a highly strain-dependent induction of anti-inflammatory cytokine interleukin 10 (IL-10). Two selected strains of Propionibacterium freudenreichii showed a protective effect against two models of colitis in mice, suggesting a probiotic potential predicted by immune-based selection criteria for these cheese starter bacteria.

Original languageEnglish
Pages (from-to)8259-8264
Number of pages6
JournalApplied and Environmental Microbiology
Volume76
Issue number24
DOIs
Publication statusPublished - Dec 2010

Keywords

  • Animals
  • Cells, Cultured
  • Colitis/prevention & control
  • Disease Models, Animal
  • Humans
  • Immunologic Factors/pharmacology
  • Interleukin-10/metabolism
  • Leukocytes, Mononuclear/immunology
  • Mice
  • Probiotics/pharmacology
  • Propionibacterium/immunology

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