Pros and Cons of Antigen-Presenting Cell Targeted Tumor Vaccines

Research output: Contribution to journalScientific review

24 Citations (Scopus)

Abstract

In therapeutic antitumor vaccination, dendritic cells play the leading role since they decide if, how, when, and where a potent antitumor immune response will take place. Since the disentanglement of the complexity and merit of different antigen-presenting cell subtypes, antitumor immunotherapeutic research started to investigate the potential benefit of targeting these subtypes in situ. This review will discuss which antigen-presenting cell subtypes are at play and how they have been targeted and finally question the true meaning of targeting antitumor-based vaccines.

Original languageEnglish
Article number785634
Number of pages8
JournalJournal of Immunology Research
Volume2015
DOIs
Publication statusPublished - 2015

Keywords

  • Animals
  • Antigen-Presenting Cells
  • Antigens, Neoplasm
  • Cancer Vaccines
  • Dendritic Cells
  • Humans
  • Immunotherapy
  • Neoplasms
  • Review

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