Protein binding domains stabilizing functional conformational states of gpcrs and uses thereof

Jan Steyaert; Els Pardon; Toon Laeremans; Brian K Kobilka; Juan Jose Fung; Soren G. F. Rasmussen

Protein binding domains stabilizing functional conformational states of gpcrs and uses thereof

Jan Steyaert (Inventor), Els Pardon (Inventor), Toon Laeremans (Inventor), Brian K Kobilka (Inventor), Juan Jose Fung (Inventor), Soren G. F. Rasmussen (Inventor)

Research output: Patent

Abstract

The present invention relates to the field of GPCR structure biology and signaling. In particular, the present invention relates to protein binding domains directed against or capable of specifically binding to a functional conformational state of a G-protein coupled receptor (GPCR). More specifically, the present invention provides protein binding domains that are capable of increasing the stability of a functional conformational state of a GPCR, in particular increasing the stability of a GPCR in its active conformational state. The protein binding domains of the present invention can be used as a tool for the structural and functional characterization of G-protein coupled receptors bound to various natural and synthetic ligands, as well as for screening and drug discovery efforts targeting GPCRs. Moreover, the invention also encompasses the diagnostic, prognostic and therapeutic usefulness of these protein binding domains for GPCR-related diseases.

Original language	English
Patent number	EP2593791B
IPC	C07K14/705,C07K14/72,C07K16/28,G01N33/543,G01N33/566,G01N33/68
Priority date	16/07/10
Filing date	18/07/11
Publication status	Published - 23 Nov 2016

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title = "Protein binding domains stabilizing functional conformational states of gpcrs and uses thereof",

abstract = "The present invention relates to the field of GPCR structure biology and signaling. In particular, the present invention relates to protein binding domains directed against or capable of specifically binding to a functional conformational state of a G-protein coupled receptor (GPCR). More specifically, the present invention provides protein binding domains that are capable of increasing the stability of a functional conformational state of a GPCR, in particular increasing the stability of a GPCR in its active conformational state. The protein binding domains of the present invention can be used as a tool for the structural and functional characterization of G-protein coupled receptors bound to various natural and synthetic ligands, as well as for screening and drug discovery efforts targeting GPCRs. Moreover, the invention also encompasses the diagnostic, prognostic and therapeutic usefulness of these protein binding domains for GPCR-related diseases.",

author = "Jan Steyaert and Els Pardon and Toon Laeremans and Kobilka, {Brian K} and Fung, {Juan Jose} and Rasmussen, {Soren G. F.}",

year = "2016",

month = nov,

day = "23",

language = "English",

publisher = "EPO",

type = "Patent",

note = "EP2593791B; C07K14/705,C07K14/72,C07K16/28,G01N33/543,G01N33/566,G01N33/68",

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TY - PAT

T1 - Protein binding domains stabilizing functional conformational states of gpcrs and uses thereof

AU - Steyaert, Jan

AU - Pardon, Els

AU - Laeremans, Toon

AU - Kobilka, Brian K

AU - Fung, Juan Jose

AU - Rasmussen, Soren G. F.

PY - 2016/11/23

Y1 - 2016/11/23

N2 - The present invention relates to the field of GPCR structure biology and signaling. In particular, the present invention relates to protein binding domains directed against or capable of specifically binding to a functional conformational state of a G-protein coupled receptor (GPCR). More specifically, the present invention provides protein binding domains that are capable of increasing the stability of a functional conformational state of a GPCR, in particular increasing the stability of a GPCR in its active conformational state. The protein binding domains of the present invention can be used as a tool for the structural and functional characterization of G-protein coupled receptors bound to various natural and synthetic ligands, as well as for screening and drug discovery efforts targeting GPCRs. Moreover, the invention also encompasses the diagnostic, prognostic and therapeutic usefulness of these protein binding domains for GPCR-related diseases.

AB - The present invention relates to the field of GPCR structure biology and signaling. In particular, the present invention relates to protein binding domains directed against or capable of specifically binding to a functional conformational state of a G-protein coupled receptor (GPCR). More specifically, the present invention provides protein binding domains that are capable of increasing the stability of a functional conformational state of a GPCR, in particular increasing the stability of a GPCR in its active conformational state. The protein binding domains of the present invention can be used as a tool for the structural and functional characterization of G-protein coupled receptors bound to various natural and synthetic ligands, as well as for screening and drug discovery efforts targeting GPCRs. Moreover, the invention also encompasses the diagnostic, prognostic and therapeutic usefulness of these protein binding domains for GPCR-related diseases.

UR - https://worldwide.espacenet.com/patent/search/family/043037319/publication/EP2593791B1?q=EP2593791

M3 - Patent

M1 - EP2593791B

Y2 - 2011/07/18

PB - EPO

ER -

Protein binding domains stabilizing functional conformational states of gpcrs and uses thereof

Abstract

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