Protein binding domains stabilizing functional conformational states of gpcrs and uses thereof

Jan Steyaert (Inventor), Els Pardon (Inventor), Soren G. F. Rasmussen (Inventor), Juan Jose Fung (Inventor), Brian K Kobilka (Inventor), Toon Laeremans (Inventor)

Research output: Patent

Abstract

The present invention relates to the field of GPCR structure biology and signaling. In particular, the present invention relates to protein binding domains directed against or capable of specifically binding to a functional conformational state of a G-protein coupled receptor (GPCR). More specifically, the present invention provides protein binding domains that are capable of increasing the stability of a functional conformational state of a GPCR, in particular increasing the stability of a GPCR in its active conformational state. The protein binding domains of the present invention can be used as a tool for the structural and functional characterization of G-protein coupled receptors bound to various natural and synthetic ligands, as well as for screening and drug discovery efforts targeting GPCRs. Moreover, the invention also encompasses the diagnostic, prognostic and therapeutic usefulness of these protein binding domains for GPCR-related diseases.
Original languageEnglish
Patent numberEP2593792B
IPCC07K14/705,G01N33/543,G01N33/566,G01N33/68
Priority date16/07/10
Filing date18/07/11
Publication statusPublished - 13 Nov 2019

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