Protein sulfenic acid formation: from cellular damage to redox regulation

Goedele Roos, Joris Messens

Research output: Contribution to journalScientific reviewpeer-review

216 Citations (Scopus)

Abstract

Protein sulfenic acid formation has long been regarded as unwanted damage caused by reactive oxygen species (ROS). However, over the past 10 years, accumulating evidence has shown that the reversible oxidation of cysteine thiol groups to sulfenic acid functions as a redox-based signal transduction mechanism. Here, we review the mechanisms of sulfenic acid formation by ROS. We present some of the most important roles played by sulfenic acids in living cells as well as the pathways that regulate sulfenic acid formation. We highlight the experimental tools that have been developed to study the cellular sulfenome and show how computational approaches might help to better understand the mechanisms of sulfenic acid formation.

Original languageEnglish
Pages (from-to)314-326
Number of pages13
JournalFree Radical Biology & Medicine
Volume51
Issue number2
DOIs
Publication statusPublished - 15 Jul 2011

Keywords

  • Molecular Probes
  • Oxidation-Reduction
  • Proteins
  • Sulfenic Acids
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review

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