Providing both autologous and allogeneic hematopoietic stem cell transplants (HSCT) may have a stronger impact on the outcome of autologous HSCT in adult patients than activity levels or implementation of JACIE at Belgian transplant centres.

HA Poirel; Marijke Vanspauwen; Gilles Macq; Anke De Geyndt; Johan Maertens; Evelyne Willems; Dominik Selleslag; X Poiré; Koen Theunissen; Carlos Graux; Tessa Kerre; Pierre Zachée; Nathalie Meuleman; Ann De Becker; Anke Verlinden; Florence Van Obbergh; Christine Schuermans; Virginie De Wilde; Aurélie Jaspers; Delphine Pranger; Dries Deeren; Ivan Van Riet; Evelien Vaes; Yves Beguin

Providing both autologous and allogeneic hematopoietic stem cell transplants (HSCT) may have a stronger impact on the outcome of autologous HSCT in adult patients than activity levels or implementation of JACIE at Belgian transplant centres.

HA Poirel, Marijke Vanspauwen, Gilles Macq, Anke De Geyndt, Johan Maertens, Evelyne Willems, Dominik Selleslag, X Poiré, Koen Theunissen, Carlos Graux, Tessa Kerre, Pierre Zachée, Nathalie Meuleman, Ann De Becker, Anke Verlinden, Florence Van Obbergh, Christine Schuermans, Virginie De Wilde, Aurélie Jaspers, Delphine PrangerDries Deeren, Ivan Van Riet, Evelien Vaes, Yves Beguin

Research output: Contribution to journal › Article

2 Citations (Scopus)

Abstract

While performance since the introduction of the JACIE quality management system has been shown to be improved for allogeneic hematopoietic stem cell transplants (HSCT), impact on autologous-HSCT remains unclear in Europe. Our study on 2697 autologous-HSCT performed in adults in 17 Belgian centres (2007–2013) aims at comparing the adjusted 1 and 3-yr survival between the different centres & investigating the impact of 3 centre-related factors on performance (time between JACIE accreditation achievement by the centre and the considered transplant, centre activity volume and type of HSCT performed by centres: exclusively autologous vs both autologous & allogeneic). We showed a relatively homogeneous performance between Belgian centres before national completeness of JACIE implementation. The 3 centre-related factors had a significant impact on the 1-yr survival, while activity volume and type of HSCT impacted the 3-yr survival of autologous-HSCT patients in univariable analyses. Only activity volume (impact on 1-yr survival only) and type of HSCT (impact on 1 and 3-yr survivals) remained significant in multivariable analysis. This is explained by the strong relationship between these 3 variables. An extended transplantation experience, i.e., performing both auto & allo-HSCT, appears to be a newly informative quality indicator potentially conveying a multitude of underlying complex factors.

Original language	English
Pages (from-to)	1434-1442
Number of pages	9
Journal	Bone Marrow Transplantation
Volume	54
Issue number	9
Publication status	Published - 1 Sep 2019

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Poirel, HA., Vanspauwen, M., Macq, G., De Geyndt, A., Maertens, J., Willems, E., ... Beguin, Y. (2019). Providing both autologous and allogeneic hematopoietic stem cell transplants (HSCT) may have a stronger impact on the outcome of autologous HSCT in adult patients than activity levels or implementation of JACIE at Belgian transplant centres. Bone Marrow Transplantation, 54(9), 1434-1442.

Poirel, HA ; Vanspauwen, Marijke ; Macq, Gilles ; De Geyndt, Anke ; Maertens, Johan ; Willems, Evelyne ; Selleslag, Dominik ; Poiré, X ; Theunissen, Koen ; Graux, Carlos ; Kerre, Tessa ; Zachée, Pierre ; Meuleman, Nathalie ; De Becker, Ann ; Verlinden, Anke ; Van Obbergh, Florence ; Schuermans, Christine ; De Wilde, Virginie ; Jaspers, Aurélie ; Pranger, Delphine ; Deeren, Dries ; Van Riet, Ivan ; Vaes, Evelien ; Beguin, Yves. / Providing both autologous and allogeneic hematopoietic stem cell transplants (HSCT) may have a stronger impact on the outcome of autologous HSCT in adult patients than activity levels or implementation of JACIE at Belgian transplant centres. In: Bone Marrow Transplantation. 2019 ; Vol. 54, No. 9. pp. 1434-1442.

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title = "Providing both autologous and allogeneic hematopoietic stem cell transplants (HSCT) may have a stronger impact on the outcome of autologous HSCT in adult patients than activity levels or implementation of JACIE at Belgian transplant centres.",

abstract = "While performance since the introduction of the JACIE quality management system has been shown to be improved for allogeneic hematopoietic stem cell transplants (HSCT), impact on autologous-HSCT remains unclear in Europe. Our study on 2697 autologous-HSCT performed in adults in 17 Belgian centres (2007–2013) aims at comparing the adjusted 1 and 3-yr survival between the different centres & investigating the impact of 3 centre-related factors on performance (time between JACIE accreditation achievement by the centre and the considered transplant, centre activity volume and type of HSCT performed by centres: exclusively autologous vs both autologous & allogeneic). We showed a relatively homogeneous performance between Belgian centres before national completeness of JACIE implementation. The 3 centre-related factors had a significant impact on the 1-yr survival, while activity volume and type of HSCT impacted the 3-yr survival of autologous-HSCT patients in univariable analyses. Only activity volume (impact on 1-yr survival only) and type of HSCT (impact on 1 and 3-yr survivals) remained significant in multivariable analysis. This is explained by the strong relationship between these 3 variables. An extended transplantation experience, i.e., performing both auto & allo-HSCT, appears to be a newly informative quality indicator potentially conveying a multitude of underlying complex factors.",

author = "HA Poirel and Marijke Vanspauwen and Gilles Macq and {De Geyndt}, Anke and Johan Maertens and Evelyne Willems and Dominik Selleslag and X Poir{\'e} and Koen Theunissen and Carlos Graux and Tessa Kerre and Pierre Zach{\'e}e and Nathalie Meuleman and {De Becker}, Ann and Anke Verlinden and {Van Obbergh}, Florence and Christine Schuermans and {De Wilde}, Virginie and Aur{\'e}lie Jaspers and Delphine Pranger and Dries Deeren and {Van Riet}, Ivan and Evelien Vaes and Yves Beguin",

year = "2019",

month = "9",

day = "1",

language = "English",

volume = "54",

pages = "1434--1442",

journal = "Bone Marrow Transplantation",

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Poirel, HA, Vanspauwen, M, Macq, G, De Geyndt, A, Maertens, J, Willems, E, Selleslag, D, Poiré, X, Theunissen, K, Graux, C, Kerre, T, Zachée, P, Meuleman, N, De Becker, A, Verlinden, A, Van Obbergh, F, Schuermans, C, De Wilde, V, Jaspers, A, Pranger, D, Deeren, D, Van Riet, I, Vaes, E & Beguin, Y 2019, 'Providing both autologous and allogeneic hematopoietic stem cell transplants (HSCT) may have a stronger impact on the outcome of autologous HSCT in adult patients than activity levels or implementation of JACIE at Belgian transplant centres.', Bone Marrow Transplantation, vol. 54, no. 9, pp. 1434-1442.

Providing both autologous and allogeneic hematopoietic stem cell transplants (HSCT) may have a stronger impact on the outcome of autologous HSCT in adult patients than activity levels or implementation of JACIE at Belgian transplant centres. / Poirel, HA; Vanspauwen, Marijke; Macq, Gilles; De Geyndt, Anke; Maertens, Johan; Willems, Evelyne; Selleslag, Dominik; Poiré, X; Theunissen, Koen; Graux, Carlos; Kerre, Tessa; Zachée, Pierre; Meuleman, Nathalie; De Becker, Ann; Verlinden, Anke; Van Obbergh, Florence; Schuermans, Christine; De Wilde, Virginie; Jaspers, Aurélie; Pranger, Delphine; Deeren, Dries; Van Riet, Ivan; Vaes, Evelien; Beguin, Yves.

In: Bone Marrow Transplantation, Vol. 54, No. 9, 01.09.2019, p. 1434-1442.

Research output: Contribution to journal › Article

TY - JOUR

T1 - Providing both autologous and allogeneic hematopoietic stem cell transplants (HSCT) may have a stronger impact on the outcome of autologous HSCT in adult patients than activity levels or implementation of JACIE at Belgian transplant centres.

AU - Poirel, HA

AU - Vanspauwen, Marijke

AU - Macq, Gilles

AU - De Geyndt, Anke

AU - Maertens, Johan

AU - Willems, Evelyne

AU - Selleslag, Dominik

AU - Poiré, X

AU - Theunissen, Koen

AU - Graux, Carlos

AU - Kerre, Tessa

AU - Zachée, Pierre

AU - Meuleman, Nathalie

AU - De Becker, Ann

AU - Verlinden, Anke

AU - Van Obbergh, Florence

AU - Schuermans, Christine

AU - De Wilde, Virginie

AU - Jaspers, Aurélie

AU - Pranger, Delphine

AU - Deeren, Dries

AU - Van Riet, Ivan

AU - Vaes, Evelien

AU - Beguin, Yves

PY - 2019/9/1

Y1 - 2019/9/1

N2 - While performance since the introduction of the JACIE quality management system has been shown to be improved for allogeneic hematopoietic stem cell transplants (HSCT), impact on autologous-HSCT remains unclear in Europe. Our study on 2697 autologous-HSCT performed in adults in 17 Belgian centres (2007–2013) aims at comparing the adjusted 1 and 3-yr survival between the different centres & investigating the impact of 3 centre-related factors on performance (time between JACIE accreditation achievement by the centre and the considered transplant, centre activity volume and type of HSCT performed by centres: exclusively autologous vs both autologous & allogeneic). We showed a relatively homogeneous performance between Belgian centres before national completeness of JACIE implementation. The 3 centre-related factors had a significant impact on the 1-yr survival, while activity volume and type of HSCT impacted the 3-yr survival of autologous-HSCT patients in univariable analyses. Only activity volume (impact on 1-yr survival only) and type of HSCT (impact on 1 and 3-yr survivals) remained significant in multivariable analysis. This is explained by the strong relationship between these 3 variables. An extended transplantation experience, i.e., performing both auto & allo-HSCT, appears to be a newly informative quality indicator potentially conveying a multitude of underlying complex factors.

AB - While performance since the introduction of the JACIE quality management system has been shown to be improved for allogeneic hematopoietic stem cell transplants (HSCT), impact on autologous-HSCT remains unclear in Europe. Our study on 2697 autologous-HSCT performed in adults in 17 Belgian centres (2007–2013) aims at comparing the adjusted 1 and 3-yr survival between the different centres & investigating the impact of 3 centre-related factors on performance (time between JACIE accreditation achievement by the centre and the considered transplant, centre activity volume and type of HSCT performed by centres: exclusively autologous vs both autologous & allogeneic). We showed a relatively homogeneous performance between Belgian centres before national completeness of JACIE implementation. The 3 centre-related factors had a significant impact on the 1-yr survival, while activity volume and type of HSCT impacted the 3-yr survival of autologous-HSCT patients in univariable analyses. Only activity volume (impact on 1-yr survival only) and type of HSCT (impact on 1 and 3-yr survivals) remained significant in multivariable analysis. This is explained by the strong relationship between these 3 variables. An extended transplantation experience, i.e., performing both auto & allo-HSCT, appears to be a newly informative quality indicator potentially conveying a multitude of underlying complex factors.

M3 - Article

VL - 54

SP - 1434

EP - 1442

JO - Bone Marrow Transplantation

JF - Bone Marrow Transplantation

SN - 0268-3369

IS - 9

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Poirel HA, Vanspauwen M, Macq G, De Geyndt A, Maertens J, Willems E et al. Providing both autologous and allogeneic hematopoietic stem cell transplants (HSCT) may have a stronger impact on the outcome of autologous HSCT in adult patients than activity levels or implementation of JACIE at Belgian transplant centres. Bone Marrow Transplantation. 2019 Sep 1;54(9):1434-1442.