Radioiodination Reactions for RadiopharmaceuticalsCompendium for Effective Synhtesisi Strategies

John Mertens, Henz Coenen, Bernard Mazière

Research output: Book/ReportBookResearch

Abstract

Several of the around 30 radioisotopes of iodine find wide application in life sciences research both in vitro and in vivo.
Most nuclear medicine departments possess one or more imaging devices for single-photon emission tomography (SPECT). Molecules of biological interest, especially for functional imaging of metabolism and neurotransmission functions using SPECT, are often labelled with 123I. In this handbook, the production methods of the six most relevant radioiodine isotopes and various methods for labelling molecules of biological interest with radioiodine are described; corresponding examples of radioiodinated pharmaceutical preparation are given and physicochemical, pharmaceutical and pharmacological properties of these radiopharmaceuticals are reviewed. Finally, an expert system providing guidelines for choosing the most appropriate method of radioiodination according to the chemical structure of the molecule of interest for tracer use is proposed.
Original languageEnglish
Place of PublicationDordrecht
PublisherSpringer
Number of pages101
ISBN (Print)1-4020-4560-3
Publication statusPublished - 2006

Keywords

  • radioiodination

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