Rail induced lateral migration of particles across intact co-flowing liquids

Iwona Ziemecka; Amaury de Hemptinne; Vyacheslav Misko; Matthieu Briet; Pierre Philippe Gelin; Ilyesse Bihi; Dominique Maes; Wim De Malsche

doi:10.1038/s41598-022-26387-5

Rail induced lateral migration of particles across intact co-flowing liquids

Iwona Ziemecka, Amaury de Hemptinne, Vyacheslav Misko, Matthieu Briet, Pierre Philippe Gelin, Ilyesse Bihi, Dominique Maes, Wim De Malsche

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

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Abstract

This paper presents a rail guided method to apply a Layer-by-Layer (LbL) coating on particles in a microfluidic device. The passive microfluidic approach allows handling suspensions of particles to be coated in the system. The trajectory of the particles is controlled using engraved rails, inducing lateral movement of particles while keeping the axially oriented liquid flow (and the interface of different liquids) undisturbed. The depth and angle of the rails together with the liquid velocity were studied to determine a workable geometry of the device. A discontinuous LbL coating procedure was converted into one continuous process, demonstrating that the chip can perform seven consecutive steps normally conducted in batch operation, further easily extendable to larger cycle numbers. Coating of the particles with two bilayers was confirmed by fluorescence microscopy.

Original language	English
Article number	21775
Number of pages	12
Journal	Scientific Reports - Nature
Volume	12
Issue number	1
DOIs	https://doi.org/10.1038/s41598-022-26387-5
Publication status	Published - Dec 2022

Bibliographical note

Funding Information:
We thank Prof. Ruslan Efremov for the use of the profilometer, and Prof. Guy van Assche and Dr. Raphael Marques for fruitful discussions. This work was partially supported by Research Foundation-Flanders (FWO-Vl), Grant No. G029322N, Grant No. 1512018N, and by Innoviris (‘Colores’ Bridge type project).

Publisher Copyright:
© 2022, The Author(s).

Copyright:
Copyright 2022 Elsevier B.V., All rights reserved.

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10.1038/s41598-022-26387-5Licence: CC BY

92811215Final published version, 2.15 MBLicence: CC BY

Cite this

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title = "Rail induced lateral migration of particles across intact co-flowing liquids",

abstract = "This paper presents a rail guided method to apply a Layer-by-Layer (LbL) coating on particles in a microfluidic device. The passive microfluidic approach allows handling suspensions of particles to be coated in the system. The trajectory of the particles is controlled using engraved rails, inducing lateral movement of particles while keeping the axially oriented liquid flow (and the interface of different liquids) undisturbed. The depth and angle of the rails together with the liquid velocity were studied to determine a workable geometry of the device. A discontinuous LbL coating procedure was converted into one continuous process, demonstrating that the chip can perform seven consecutive steps normally conducted in batch operation, further easily extendable to larger cycle numbers. Coating of the particles with two bilayers was confirmed by fluorescence microscopy.",

author = "Iwona Ziemecka and {de Hemptinne}, Amaury and Vyacheslav Misko and Matthieu Briet and Gelin, {Pierre Philippe} and Ilyesse Bihi and Dominique Maes and {De Malsche}, Wim",

note = "Funding Information: We thank Prof. Ruslan Efremov for the use of the profilometer, and Prof. Guy van Assche and Dr. Raphael Marques for fruitful discussions. This work was partially supported by Research Foundation-Flanders (FWO-Vl), Grant No. G029322N, Grant No. 1512018N, and by Innoviris ({\textquoteleft}Colores{\textquoteright} Bridge type project). Publisher Copyright: {\textcopyright} 2022, The Author(s). Copyright: Copyright 2022 Elsevier B.V., All rights reserved.",

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doi = "10.1038/s41598-022-26387-5",

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AU - de Hemptinne, Amaury

AU - Misko, Vyacheslav

AU - Briet, Matthieu

AU - Gelin, Pierre Philippe

AU - Bihi, Ilyesse

AU - Maes, Dominique

AU - De Malsche, Wim

N1 - Funding Information: We thank Prof. Ruslan Efremov for the use of the profilometer, and Prof. Guy van Assche and Dr. Raphael Marques for fruitful discussions. This work was partially supported by Research Foundation-Flanders (FWO-Vl), Grant No. G029322N, Grant No. 1512018N, and by Innoviris (‘Colores’ Bridge type project). Publisher Copyright: © 2022, The Author(s). Copyright: Copyright 2022 Elsevier B.V., All rights reserved.

PY - 2022/12

Y1 - 2022/12

N2 - This paper presents a rail guided method to apply a Layer-by-Layer (LbL) coating on particles in a microfluidic device. The passive microfluidic approach allows handling suspensions of particles to be coated in the system. The trajectory of the particles is controlled using engraved rails, inducing lateral movement of particles while keeping the axially oriented liquid flow (and the interface of different liquids) undisturbed. The depth and angle of the rails together with the liquid velocity were studied to determine a workable geometry of the device. A discontinuous LbL coating procedure was converted into one continuous process, demonstrating that the chip can perform seven consecutive steps normally conducted in batch operation, further easily extendable to larger cycle numbers. Coating of the particles with two bilayers was confirmed by fluorescence microscopy.

AB - This paper presents a rail guided method to apply a Layer-by-Layer (LbL) coating on particles in a microfluidic device. The passive microfluidic approach allows handling suspensions of particles to be coated in the system. The trajectory of the particles is controlled using engraved rails, inducing lateral movement of particles while keeping the axially oriented liquid flow (and the interface of different liquids) undisturbed. The depth and angle of the rails together with the liquid velocity were studied to determine a workable geometry of the device. A discontinuous LbL coating procedure was converted into one continuous process, demonstrating that the chip can perform seven consecutive steps normally conducted in batch operation, further easily extendable to larger cycle numbers. Coating of the particles with two bilayers was confirmed by fluorescence microscopy.

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Rail induced lateral migration of particles across intact co-flowing liquids

Abstract

Bibliographical note

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Rail induced lateral migration of particles across intact co-flowing liquids

Abstract

Bibliographical note

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SRP51: SRP-Onderzoekszwaartepunt: Optical and microfluidic tools to unravel the dynamics of bio-condensates

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