Randall's plaque as the origin of idiopathic calcium oxalate stone formation: an update

Els Van de Perre, Dominique Bazin, Vincent Estrade, Elise Bouderlique, Karl Martin Wissing, Michel Daudon, Emmanuel Letavernier

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)
18 Downloads (Pure)


The majority of idiopathic calcium oxalate kidney stones form on the Randall's plaque, a subepithelial calcium phosphate plaque at the renal papilla. The formation mechanisms of the Ran-dall's plaque and associated calcium oxalate stones remain incompletely understood. This article pro-vides an historical overview of the research performed on this topic, describes the current epidemi-ological trends of Randall's plaque-associated kidney stone formation and reviews the suggested for-mation mechanisms of Randall's plaque and associated calcium oxalate stones. Finally, this overview highlights the recent advances made on the subject, including the development of an animal model.
Original languageEnglish
Pages (from-to)373-391
Number of pages18
JournalComptes rendus. Chimie
Issue numberS1
Publication statusPublished - 2022

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  • Randall's plaque
  • Calcium phosphate
  • Calcium oxlate stones
  • Kidney stones
  • Nephrolithiasis


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