Randomised clinical trial : the synbiotic food supplement probiotical vs placebo for acute gastroenteritis in children

Yvan Vandenplas, S. De Hert

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

BACKGROUND: Some probiotic strains reduce the duration of acute diarrhoea. As a result of strain and product specificity, each product needs support by clinical data.

AIM: In children with acute diarrhoea, to test the efficacy of the synbiotic food supplement Probiotical (Streptoccoccus thermophilus, Lactobacillus rhamnosus, Lactobacillus acidophilus, Bifidobacterium lactis, Bifidobacterium infantis, fructo-oligosaccharides). The primary end-points were duration of diarrhoea and the number of children that had a normalised stool consistency.

METHOD: A total of 111 children with acute diarrhoea (median age 40 months) were included in this randomised, prospective placebo-controlled parallel clinical trial in primary health care. All children were treated with oral rehydration solution ad libitum and with the synbiotic (n=57) or placebo (n = 54).

RESULTS: The median duration of diarrhoea was 3 days (IQ 25-75: 2-4 days) in the Probiotical group, compared with 4 days (IQ 25-75: 4-5 days) in the placebo group (P
CONCLUSION: The median duration of diarrhoea was significantly 1 day shorter in the synbiotic than in the placebo group, associated with decreased prescription of additional medications.
Original languageEnglish
Pages (from-to)862-867
Number of pages6
JournalAliment Pharmacol Ther
Volume34
Issue numberoct
Publication statusPublished - 1 Oct 2011

Keywords

  • probiotical
  • acute gastroenteritis

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