Rational and design of EuroCRT: an international observational study on multi-modality imaging and cardiac resynchronization therapy

Erwan Donal, Victoria Delgado, Julien Magne, Chiara Bucciarelli-Ducci, Christophe Leclercq, Bernard Cosyns, Marta Sitges, Thor Edvardsen, Elif Sade, Ivan Stankovic, Eustachio Agricola, Maurizio Galderisi, Patrizio Lancellotti, Alfredo Hernandez, Sven Plein, Denisa Muraru, Ehud Schwammenthal, Gerhard Hindricks, Bogdan A. Popescu, Gilbert Habib

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16 Citations (Scopus)

Abstract

Aims Assessment of left ventricular (LV) volumes and ejection fraction (LVEF) with cardiac imaging is important in the selection of patients for cardiac resynchronization therapy (CRT). Several observational studies have explored the role of imaging-derived LV dyssynchrony parameters to predict the response to CRT, but have yielded inconsistent results, precluding the inclusion of imaging-derived LV dyssynchrony parameters in current guidelines for selection of patients for CRT.
Methods The EuroCRT is a large European multicentre prospective observational study led by the European Association of Cardiovascular Imaging. We aim to explore if combing the value of cardiac magnetic resonance (CMR) and echocardiography could be beneficial for selecting heart failure patients for CRT in terms of improvement in long-term survival, clinical symptoms, LV function, and volumes. Speckle tracking echocardiography will be used to assess LV dyssynchrony and wasted cardiac work whereas myocardial scar will be assessed with late gadolinium contrast enhanced CMR. All data will be measured in core laboratories. The study will be conducted in European centres with known expertise in both CRT and multimodality cardiac imaging.
Original languageEnglish
Pages (from-to)1120-1127
Number of pages8
JournalEuropean Heart Journal - Cardiovascular Imaging
Volume18
Issue number10
DOIs
Publication statusPublished - Oct 2017

Bibliographical note

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2017. For permissions, please email: journals.permissions@oup.com.

Keywords

  • Aged
  • Cardiac Imaging Techniques/methods
  • Cardiac Resynchronization Therapy/methods
  • Cohort Studies
  • Confidence Intervals
  • Echocardiography/methods
  • Europe
  • Female
  • Heart Failure/mortality
  • Humans
  • Internationality
  • Magnetic Resonance Imaging, Cine/methods
  • Male
  • Middle Aged
  • Multimodal Imaging/methods
  • Predictive Value of Tests
  • Prognosis
  • Prospective Studies
  • Risk Assessment
  • Statistics, Nonparametric
  • Survival Rate
  • Treatment Outcome
  • Ventricular Dysfunction, Left/diagnostic imaging
  • Ventricular Remodeling/physiology

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