Rational design of a hexapeptide hydrogelator for controlled-release drug delivery: IF 4.872

Mathieu Bibian, Jeroen Mangelschots, James Gardiner, Lynne Waddington, Maria M. Diaz Acevedo, Bruno G. De Geest, Bruno Van Mele, Annemieke Madder, Richard Hoogenboom, Steven Ballet

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The amphiphilic peptide sequence H-Phe-Glu-Phe-Gln-Phe-Lys-OH (MBG-1) is developed as a novel hydrogelator for use in controlled-drug release administration, which is the smallest tunable ionic selfcomplementary hydrogelating peptide reported to date making it attractive for larger scale preparation. Hydrogelation is demonstrated to result from self-assembly of the peptide into beta-sheet nanofibers that are physically cross-linked by intertwining as well as larger bundle formation. Finally, the release of two small molecule cargos, fluorescein sodium and ciprofloxacin hydrochloride, is demonstrated revealing a two-stage zero-order sustained release profile up to 80% cumulative release over eight days.
Original languageEnglish
Pages (from-to)759-765
Number of pages7
JournalJournal of Materials Chemistry B
Volume3
Issue number5
DOIs
Publication statusPublished - 2015

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