RE-Place: A Unique Project Collecting Expertise on New Approach Methodologies

Mieke Van Mulders, Maude Everaert, Nancy Marie Antonia Liodo Missigba, Birgit Mertens, Vera Rogiers

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)
9 Downloads (Pure)

Abstract

By applying “New Approach Methodologies (NAMs)” based on innovative technologies such as computer modeling, high throughput testing, omics, and sophisticated cell cultures, the use of experimental animals in the life sciences can be reduced or sometimes even completely avoided. Stimulating NAMs may benefit from a bottom-up approach, i.e., local initiatives mapping the available NAMs and promoting their use. An example of such an initiative in Belgium is the RE-Place project, which collects the available NAMs in one central database, and links this knowledge with the names of experts and research centers. To this extent, a template was created to collect the information of interest in a fast and consistent manner. Based on this template, a web-based application was developed to facilitate the entry of information, which was evaluated in a pilot study by experts in the field of NAMs. After integration of their feedback, a revised version of the RE-Place online tool was launched to the public. Aspects such as user-friendliness, quality of submitted information, protection of personal data and Intellectual Property (IP) rights were all considered in the development process. Hurdles like incentives for collaboration were also taken into account. Information submitted with the online tool is directly integrated in the RE-Place open access database. By consulting the database, scientists from various disciplines can easily identify the different types of NAMs and the experts using them in Belgium. As such, the RE-Place database contributes to building trust in the use of NAMs and stimulating their use and regulatory uptake.
Original languageEnglish
Article number930148
Pages (from-to)930148
Number of pages12
JournalFrontiers in Pharmacology
Volume13
DOIs
Publication statusPublished - 22 Jun 2022

Bibliographical note

Funding Information:
The RE-Place project is financed by the departments of Animal Welfare from the Flemish and Brussels Capital region in Belgium. Funding of the Flemish region includes following grant numbers: LNE/STG/DWZ/16/05 and DO/SID/DWZ/OO/19/09. Funding of the Brussels Capital region includes following grant numbers: SUB/2017/VUB/BEA/KADASTER, SUB/2018/VUB/BEA/KADASTER, SUB/2019/VUB/BEA/KADASTER, SUB/2020/VUB/BEA/KADASTER, SUB/2021/VUB/BEA/KADASTER. Also internal resources of Sciensano and the VUB have been provided.

Funding Information:
The RE-Place project is financed by the departments of Animal Welfare from the Flemish and Brussels Capital region in Belgium. Funding of the Flemish region includes following grant numbers: LNE/STG/DWZ/16/05 and DO/SID/DWZ/OO/19/09. Funding of the Brussels Capital region includes following grant numbers: SUB/2017/VUB/BEA/KADASTER, SUB/2018/VUB/BEA/KADASTER, SUB/2019/VUB/BEA/KADASTER, SUB/2020/VUB/BEA/KADASTER, SUB/2021/VUB/BEA/KADASTER. Also internal resources of Sciensano and the VUB have been provided.

Publisher Copyright:
Copyright © 2022 Van Mulders, Liodo Missigba, Mertens and Rogiers.

Copyright:
Copyright 2022 Elsevier B.V., All rights reserved.

Keywords

  • 3Rs
  • NAMs
  • New Approach Methodologies
  • Alternative approaches
  • non-animal methods
  • replacement
  • open access
  • database
  • knowledge sharing
  • RE-Place
  • alternative methods to animal testing

Fingerprint

Dive into the research topics of 'RE-Place: A Unique Project Collecting Expertise on New Approach Methodologies'. Together they form a unique fingerprint.

Cite this