Projects per year
Abstract
Adult neurotoxicity (ANT) and developmental neurotoxicity (DNT) assessments aim to understand the adverse effects and underlying mechanisms of toxicants on the human nervous system. In recent years, there has been an increasing focus on the so-called new approach methodologies (NAMs). The Organization for Economic Co-operation and Development (OECD), together with European and American regulatory agencies, promote the use of validated alternative test systems, but to date, guidelines for regulatory DNT and ANT assessment rely primarily on classical animal testing. Alternative methods include both non-animal approaches and test systems on non-vertebrates (e.g., nematodes) or non-mammals (e.g., fish). Therefore, this review summarizes the recent advances of NAMs focusing on ANT and DNT and highlights the potential and current critical issues for the full implementation of these methods in the future. The status of the DNT in vitro battery (DNT IVB) is also reviewed as a first step of NAMs for the assessment of neurotoxicity in the regulatory context. Critical issues such as (i) the need for test batteries and method integration (from in silico and in vitro to in vivo alternatives, e.g., zebrafish, C. elegans) requiring interdisciplinarity to manage complexity, (ii) interlaboratory transferability, and (iii) the urgent need for method validation are discussed.
Original language | English |
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Pages (from-to) | 1271-1295 |
Number of pages | 25 |
Journal | Archives of Toxicology |
Volume | 98 |
Issue number | 5 |
DOIs | |
Publication status | Published - 13 Mar 2024 |
Bibliographical note
Publisher Copyright:© The Author(s) 2024.
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Dive into the research topics of 'Recent advances and current challenges of new approach methodologies in developmental and adult neurotoxicity testing'. Together they form a unique fingerprint.Projects
- 1 Finished
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EUAR35: H2020: CSA: TWINALT: Twinning towards excellence in alternative methods for toxicity assessment
Vanhaecke, T., De Kock, J., Marcelino Rodrigues, R. & Rogiers, V.
1/09/20 → 31/08/23
Project: Applied