Recent advances and prospects in the differentiation of pancreatic cells from human embryonic stem cells

Josue Mfopou Kunjom, Bing Chen, Lina Sui, Karen Sermon, Luc Bouwens

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Recent studies with human embryonic stem (hES) cells have established new protocols for substantial generation of pancreatic progenitors from definitive endoderm. These findings add to the efficient derivation of definitive endoderm, which is controlled by Wnt and Nodal pathways, and delineate a step forward in the quest for alternative beta cell sources. It also indicates that critical refining of the available strategies might help define a universal protocol for pancreatic differentiation applicable to several cell lines, therefore offering the possibility for transplantation of immune-matched, or patient-specific hES-derived beta cells. We appraise here the fundamental role that BMP, FGF and retinoid signalings play during pancreas development, and describe a fundamental emergence of their combination in recent studies that generated pancreatic cells from hES cells. We finally enumerate some prospects that might improve further differentiation of the progenitor cells into functional beta cells needed in diabetes cell therapy.
Original languageEnglish
Pages (from-to)2094-2101
Number of pages13
JournalDiabetes
Volume59
Publication statusPublished - 2010

Keywords

  • human embryonic stem cell
  • definitive endoderm
  • pancreatic progenitor
  • bone morphogenetic protein
  • retinoic acid
  • pdx1
  • insulin
  • hepatocyte

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