Recurrent chromosomal abnormalities in human embryonic stem cells.

Claudia Spits; Ileana Mateizel; Mieke Geens; Afroditi Mertzanidou; C. Staessen; Yves Vandeskelde; Josiane Van Der Elst; Ingeborg Liebaers; Karen Sermon

Recurrent chromosomal abnormalities in human embryonic stem cells.

Claudia Spits, Ileana Mateizel, Mieke Geens, Afroditi Mertzanidou, C. Staessen, Yves Vandeskelde, Josiane Van Der Elst, Ingeborg Liebaers, Karen Sermon

Department of Embryology and Genetics

Research output: Contribution to journal › Article › peer-review

202 Citations (Scopus)

Abstract

Cultured human embryonic stem (hES) cells have a known predisposition to aneuploidy of chromosomes 12, 17 and X. We studied 17 hES cell lines by array-based comparative genomic hybridization (aCGH) and found that the cells accumulate other recurrent chromosomal abnormalities, including amplification at 20q11.21 and a derivative chromosome 18. These genomic changes have a variable impact at the transcriptional level.

Original language	English
Pages (from-to)	1361-1363
Number of pages	3
Journal	Nat Biotechnol
Volume	26
Issue number	December
Publication status	Published - Dec 2008

Keywords

MOLECULAR KARYOTYPING
human embryonic stem cells

Access to Document

http://www.ncbi.nlm.nih.gov/pubmed/19029912?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

FWOAL469: Epi(genetic) stability in gametes, preimplantation embryos and human embryonic stem cells with a focus on the behaviour of dynamic mutations causing myotonic dystrophy and fragile X syndrome
Spits, C., Sermon, K. & Liebaers, I.
1/01/08 → 31/12/11
Project: Fundamental
OZR1601: Epi(genetic) stability in gametes, preimplantation embryos and human embryonic stem cells with a focus on the behaviour of dynamic mutations causing myotonic dystrophy and fragile X syndrome
Liebaers, I., Spits, C. & Sermon, K.
1/01/08 → 31/12/08
Project: Fundamental
EU276: Stem cells for therapeutics and exploration of mechanisms in Huntingtons disease
Sermon, K.
1/12/06 → 30/11/09
Project: Fundamental

Cite this

Spits, C., Mateizel, I., Geens, M., Mertzanidou, A., Staessen, C., Vandeskelde, Y., Van Der Elst, J., Liebaers, I., & Sermon, K. (2008). Recurrent chromosomal abnormalities in human embryonic stem cells. Nat Biotechnol, 26(December), 1361-1363. http://www.ncbi.nlm.nih.gov/pubmed/19029912?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

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title = "Recurrent chromosomal abnormalities in human embryonic stem cells.",

abstract = "Cultured human embryonic stem (hES) cells have a known predisposition to aneuploidy of chromosomes 12, 17 and X. We studied 17 hES cell lines by array-based comparative genomic hybridization (aCGH) and found that the cells accumulate other recurrent chromosomal abnormalities, including amplification at 20q11.21 and a derivative chromosome 18. These genomic changes have a variable impact at the transcriptional level.",

keywords = "MOLECULAR KARYOTYPING, human embryonic stem cells",

author = "Claudia Spits and Ileana Mateizel and Mieke Geens and Afroditi Mertzanidou and C. Staessen and Yves Vandeskelde and {Van Der Elst}, Josiane and Ingeborg Liebaers and Karen Sermon",

year = "2008",

month = dec,

language = "English",

volume = "26",

pages = "1361--1363",

journal = "Nature Biotechnology",

issn = "1087-0156",

publisher = "Nature Publishing Group",

number = "December",

}

Spits, C , Mateizel, I, Geens, M, Mertzanidou, A, Staessen, C, Vandeskelde, Y, Van Der Elst, J, Liebaers, I & Sermon, K 2008, 'Recurrent chromosomal abnormalities in human embryonic stem cells.', Nat Biotechnol, vol. 26, no. December, pp. 1361-1363. <http://www.ncbi.nlm.nih.gov/pubmed/19029912?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum>

TY - JOUR

T1 - Recurrent chromosomal abnormalities in human embryonic stem cells.

AU - Spits, Claudia

AU - Mateizel, Ileana

AU - Geens, Mieke

AU - Mertzanidou, Afroditi

AU - Staessen, C.

AU - Vandeskelde, Yves

AU - Van Der Elst, Josiane

AU - Liebaers, Ingeborg

AU - Sermon, Karen

PY - 2008/12

Y1 - 2008/12

N2 - Cultured human embryonic stem (hES) cells have a known predisposition to aneuploidy of chromosomes 12, 17 and X. We studied 17 hES cell lines by array-based comparative genomic hybridization (aCGH) and found that the cells accumulate other recurrent chromosomal abnormalities, including amplification at 20q11.21 and a derivative chromosome 18. These genomic changes have a variable impact at the transcriptional level.

AB - Cultured human embryonic stem (hES) cells have a known predisposition to aneuploidy of chromosomes 12, 17 and X. We studied 17 hES cell lines by array-based comparative genomic hybridization (aCGH) and found that the cells accumulate other recurrent chromosomal abnormalities, including amplification at 20q11.21 and a derivative chromosome 18. These genomic changes have a variable impact at the transcriptional level.

KW - MOLECULAR KARYOTYPING

KW - human embryonic stem cells

M3 - Article

VL - 26

SP - 1361

EP - 1363

JO - Nature Biotechnology

JF - Nature Biotechnology

SN - 1087-0156

IS - December

ER -

Recurrent chromosomal abnormalities in human embryonic stem cells.

Abstract

Keywords

Access to Document

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Projects

FWOAL469: Epi(genetic) stability in gametes, preimplantation embryos and human embryonic stem cells with a focus on the behaviour of dynamic mutations causing myotonic dystrophy and fragile X syndrome

OZR1601: Epi(genetic) stability in gametes, preimplantation embryos and human embryonic stem cells with a focus on the behaviour of dynamic mutations causing myotonic dystrophy and fragile X syndrome

EU276: Stem cells for therapeutics and exploration of mechanisms in Huntingtons disease

Cite this