Recurrent chromosomal abnormalities in human embryonic stem cells.

Claudia Spits, Ileana Mateizel, Mieke Geens, Afroditi Mertzanidou, C. Staessen, Yves Vandeskelde, Josiane Van Der Elst, Ingeborg Liebaers, Karen Sermon

Research output: Contribution to journalArticle

185 Citations (Scopus)

Abstract

Cultured human embryonic stem (hES) cells have a known predisposition to aneuploidy of chromosomes 12, 17 and X. We studied 17 hES cell lines by array-based comparative genomic hybridization (aCGH) and found that the cells accumulate other recurrent chromosomal abnormalities, including amplification at 20q11.21 and a derivative chromosome 18. These genomic changes have a variable impact at the transcriptional level.
Original languageEnglish
Pages (from-to)1361-1363
Number of pages3
JournalNat Biotechnol
Volume26
Issue numberDecember
Publication statusPublished - Dec 2008

Keywords

  • MOLECULAR KARYOTYPING
  • human embryonic stem cells

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