Refinement in Animal EPilepsy Models

Ralph Clinckers

Research output: Chapter in Book/Report/Conference proceedingConference paper

Abstract

In epilepsy research there are several objectives, such as unravelling the pathogenesis of
epilepsy, identifying new drug targets and drug screening. To this end, two models are
used, the seizure and epilepsy models. Seizure models have been used for years and are
still used in the study of epilepsy. They have been very helpful in understanding the basic
mechanisms of epilepsy and for screening new antiepileptic drugs. Nowadays,
antiepileptic drugs work on suppressing the seizures of patients. However, in a number of
cases, the drugs do not work and the seizure persists, so there is a need for drugs which
completely prevent epilepsy. For this purpose, animal epilepsy models are used.
A number of techniques is used to maximize the number of read outs obtained from an
animal in an acute seizure or chronic epilepsy model, which thus helps to refining the
research to this disease.
Original languageEnglish
Title of host publicationUnknown
Publication statusPublished - 2009
EventFinds and Results from the Swedish Cyprus Expedition: A Gender Perspective at the Medelhavsmuseet - Stockholm, Sweden
Duration: 21 Sep 200925 Sep 2009

Conference

ConferenceFinds and Results from the Swedish Cyprus Expedition: A Gender Perspective at the Medelhavsmuseet
CountrySweden
CityStockholm
Period21/09/0925/09/09

Keywords

  • refinement
  • epilepsy
  • animal models

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